ArticleInternational journal of cardiology. Heart & vasculature2026
Prevalence and prognostic implications of chronic kidney disease in patients with atrial functional mitral regurgitation.
Article in International journal of cardiology. Heart & vasculature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Atrial functional mitral regurgitation (AFMR) is increasingly recognized as a distinct mitral regurgitation subtype; the prognostic impact of coexisting chronic kidney disease (CKD) remains unclear. Methods: Data from 989 patients enrolled in the multicenter REVEAL-AFMR registry were analyzed. Coexisting CKD was defined as reduced estimated glomerular filtration rate (eGFR) < 60 mL/min/1.73 m Results: Coexisting CKD was present in 429 of 989 patients (43.4%). Lower eGFR was associated with more advanced mitral regurgitation (MR), higher BNP levels, and more severe heart failure symptoms. Over a median follow-up of 1002 days, 181 patients (18.3%) experienced the primary endpoint. The cumulative incidence of the primary endpoint increased stepwise across CKD stages (log-rank Conclusion: Among conservatively managed patients with AFMR, CKD is common in AFMR, and CKD stage is independently associated with worse outcomes in a graded manner, irrespective of MR severity. Renal function assessment may improve AFMR risk stratification.
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