Evidence map›Paper›PMID 42472846›Full record

SynthesisCritical care (London, England)2026

Hemoperfusion during extracorporeal membrane oxygenation: an updated systematic review and meta-analysis of 8,151 patients.

Ting Xie, Chengyi Yang, Heng Tao, Xueting Yang, Lei Deng, Jun Zeng, Hua Jiang, Ping Zhou

Abstract readSystematic ReviewMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Critical care (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Ting Xie *Intensive Care Unit, Department of Emergency Medicine, Sichuan Provincial People's Hospital, Affiliated Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Chengyi Yang *Intensive Care Unit, Department of Emergency Medicine, Sichuan Provincial People's Hospital, Affiliated Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Heng TaoIntensive Care Unit, Department of Emergency Medicine, Sichuan Provincial People's Hospital, Affiliated Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Xueting YangIntensive Care Unit, Department of Emergency Medicine, Sichuan Provincial People's Hospital, Affiliated Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Lei DengIntensive Care Unit, Department of Emergency Medicine, Sichuan Provincial People's Hospital, Affiliated Hospital of University of Electronic Science and Technology of China, Chengdu, China.
Jun ZengInstitute for Emergency and Disaster Medicine, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. zengjun@med.uestc.edu.cn.
Hua JiangInstitute for Emergency and Disaster Medicine, School of Medicine, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China. jianghua@uestc.edu.cn.
Ping ZhouIntensive Care Unit, Department of Emergency Medicine, Sichuan Provincial People's Hospital, Affiliated Hospital of University of Electronic Science and Technology of China, Chengdu, China. zp_319@163.com.

Funding

Health Department of Sichuan Province ChuanJianYan ZH2025-201
6 · The paper itself

Abstract

backgroundThis systematic review and meta-analysis evaluated the clinical efficacy and safety of hemoperfusion in adults receiving extracorporeal membrane oxygenation (ECMO).

methodsWe systematically searched PubMed, Embase, the Cochrane Library, CNKI, and CBM for studies comparing ECMO plus hemoperfusion (ECMO + HP) with ECMO alone in adult patients. The primary outcome was all-cause mortality. Prespecified subgroup analyses were conducted according to study design (RCT vs non-RCT), ECMO type (VA vs VV), and etiology (cardiogenic shock vs cardiac arrest). Risk of bias was assessed using RoB 2.0 and ROBINS-I, and Trial Sequential Analysis (TSA) was performed. The systematic review was registered with PROSPERO (CRD42025643149) and conducted in accordance with PRISMA guidelines.

resultsThirteen studies involving 8,151 patients were included, comprising three RCTs and ten non-RCTs. Overall, ECMO + HP did not significantly reduce all-cause mortality compared with ECMO alone (OR 0.98, 95% CI 0.49-1.94; P = 0.95; I

conclusionIn patients receiving extracorporeal membrane oxygenation, hemoperfusion did not reduce mortality and may be associated with increased mortality in randomized controlled trials. Current evidence does not support routine use of ECMO + HP in ICU condition.

Indexed as

Extracorporeal Membrane OxygenationHemoperfusionHumansCritical illnessCytokine adsorptionExtracorporeal membrane oxygenationHemoperfusionInflammatory biomarkers

Identifiers

PMID42472846
PMCPMC13644233

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.