Evidence map›Paper›PMID 42472934›Full record

ArticleEuropean archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery2026

Septal flip flap after endoscopic unilateral resection of sinonasal tumors: a multicenter experience of 133 patients.

Alessandro Vinciguerra, Mario Turri-Zanoni, Marco Ferrari, Vittorio Rampinelli, Florian Chatelet, Davide Mattavelli, Alberto Schreiber, Stefano Taboni, Federico Russo, Piergiorgio Gaudioso and 7 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
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Article in European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Alessandro VinciguerraDivision of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Lariana, Como, Italy. a.vinciguerra.md@gmail.com.ORCID http://orcid.org/0000-0003-4805-4908
Mario Turri-ZanoniDivision of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Lariana, Como, Italy.
Marco FerrariSection of Otorhinolaryngology - Head and Neck Surgery, Department of Neuroscience (DNS), University of Padova, Padova, Italy.
Vittorio RampinelliUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Florian ChateletOtorhinolaryngology and Skull Base Center, AP-HP, Hospital Lariboisière, Université Paris Cité, Paris, France.
Davide MattavelliUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Alberto SchreiberUnit of Otorhinolaryngology, Manerbio and Desenzano Hospitals, ASST del Garda, Brescia, Italy.
Stefano TaboniUnit of Otorhinolaryngology - Head and Neck Surgery, Azienda Ospedale- Università Padova, Padova, Italy.
Federico RussoDivision of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Lariana, Como, Italy.
Piergiorgio GaudiosoUnit of Otorhinolaryngology - Head and Neck Surgery, Azienda Ospedale- Università Padova, Padova, Italy.
Benjamin VerillaudOtorhinolaryngology and Skull Base Center, AP-HP, Hospital Lariboisière, Université Paris Cité, Paris, France.
Cesare PiazzaUnit of Otorhinolaryngology-Head and Neck Surgery, ASST Spedali Civili Brescia, Department of Medical and Surgical Specialties, Radiological Sciences, and Public Health, University of Brescia, Brescia, Italy.
Paolo CastelnuovoDivision of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Lariana, Como, Italy.
Piero NicolaiSection of Otorhinolaryngology - Head and Neck Surgery, Department of Neuroscience (DNS), University of Padova, Padova, Italy.
Maurizio BignamiDivision of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, Ospedale di Circolo, Varese, Italy.
Philippe HermanOtorhinolaryngology and Skull Base Center, AP-HP, Hospital Lariboisière, Université Paris Cité, Paris, France.
Paolo BattagliaDivision of Otorhinolaryngology, Department of Biotechnology and Life Sciences, University of Insubria, ASST Lariana, Como, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSkull base reconstruction after endoscopic resection of sinonasal tumors remains challenging, particularly in preventing cerebrospinal fluid leaks. Autologous grafts are traditionally favored, whereas non-autologous materials may reduce donor-site morbidity with similar success. In this study, we explore surgical outcomes in patients undergoing unilateral resection of sinonasal tumors reconstructed with the septal flip flap (SFF), focusing on the impact of graft type on the efficacy and safety of the reconstructive strategy.

methodsThis multicenter retrospective cohort study included adult patients with malignant sinonasal tumors treated via unilateral endoscopic resection and SFF reconstruction. Clinical and surgical variables were analyzed to identify predictors of early postoperative complications and factors influencing hospitalization using univariate and multivariate methods.

resultsA total of 133 patients were included. Early postoperative complications occurred in 9.7%, with 4.5% related to skull base reconstruction. No variables, including graft type, significantly predicted SB-related complications in univariate logistic regression. Autologous grafts were associated with increased use of adjuvant radiotherapy (67.1% vs. 36.8%, p = 0.015). Conversely, the median hospitalization was 7 days. Dura mater resection, autologous graft use, early complications, and prior treatment were independent predictors of prolonged hospitalization at multivariate linear regression.

conclusionThis multicenter study confirms SFF as a reliable and safe option for anterior skull base reconstruction following unilateral sinonasal malignancy resection. The technique achieved robust closure, no flap necrosis, and low reconstruction-related complication rates. Graft type did not significantly influence outcomes, although autologous grafts provided better integration in patients receiving adjuvant radiotherapy, while non-autologous substitutes proved equally safe and effective in selected unimodal settings.

Indexed as

EndoscopyNasal SeptumNose NeoplasmsParanasal Sinus NeoplasmsPlastic Surgery ProceduresSkull BaseSurgical FlapsAdultAgedFemaleHumansMaleMiddle AgedPostoperative ComplicationsRetrospective StudiesTreatment Outcome

Identifiers

PMID42472934
PMCPMC13615011

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.