ArticleJournal of clinical periodontology2026
Twenty-Five-Year Follow-Up of Individuals With Intact Periodontium and Differing Susceptibility to Experimentally Induced Gingival Inflammation.
Article in Journal of clinical periodontology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo evaluate the periodontal condition of individuals with different susceptibility to dental biofilm-induced gingivitis 25 years after their classification as high responders (HR) or low responders (LR) to plaque.
methodsForty-eight systemically and periodontally healthy young adults who participated in a 21-day experimental gingivitis trial in 2000-2001 and exhibited either markedly pronounced (HR, n = 24) or milder (LR, n = 24) gingival inflammation despite similar supragingival plaque exposure were invited to a follow-up visit, during which a periodontal diagnosis was established.
resultsNine LR and eight HR individuals accepted to participate. Among the LR participants, six (67%) were diagnosed as periodontally healthy or with gingivitis, whereas 100% of HR participants were diagnosed with periodontitis (p = 0.009). Compared to LR, HR individuals presented higher bleeding on probing score (39.5% ± 13.8% vs. 15.0% ± 10.1%; p = 0.003) as well as a higher proportion of visibly inflamed sites (p < 0.001). Intergroup differences could not be explained by other variables, including full-mouth plaque score, oral hygiene habits or adherence to supportive care.
conclusionsThis study, based on a very limited sample size and therefore hypothesis-generating rather than confirmatory, suggests that susceptibility to biofilm-induced gingivitis may help identify individuals at different risks of periodontitis.
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