ReviewInternational journal of nanomedicine2026
Nanoscale Delivery of MicroRNAs via Extracellular Vesicles: Mechanisms Potential in Modulating Cellular Senescence.
Review in International journal of nanomedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Senescence refers to the gradual decline in function and physiological integrity of organisms over time, signifying an irreversible natural process of life. Senescence is associated with abnormal alterations in intercellular communication, where signaling molecules exchanged between cells can either accelerate or impede this process. In the rapidly evolving field of nanomedicine, extracellular vesicles (EVs) have emerged as natural nanoscale delivery vehicles that facilitate the highly efficient transfer of diverse cargoes, including microRNAs (miRNAs), DNA, lipids, and proteins. Compared to synthetic nanocarriers, EVs possess superior biocompatibility and the unique ability to cross biological barriers. MiRNAs encapsulated within these endogenous nanoparticles have demonstrated the ability to regulate several aging processes both in vivo and in vitro. Notably, although there are still some challenges regarding the clinical translation of EV-derived miRNAs from stem cells, macrophages, and the circulatory system, their potential for nanotherapeutic applications in the field of anti-aging remains undeniable.Here, we comprehensively summarize the regulatory functions of EV-delivered miRNAs during the aging process and propose novel bio-inspired nanomedicine strategies for the anti-aging applications of EVs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.