Prognostic value of endothelial activation and stress index (EASIX) on short-term and long-term outcomes in type B aortic dissection after thoracic endovascular repair: An observational study.

Objective: The association between endothelial activation and stress index (EASIX) and both short-term and long-term outcomes in patients with type B aortic dissection (TBAD) undergoing thoracic endovascular repair (TEVAR) remains unclear. This study aimed to explore this relationship. Methods: We conducted a retrospective analysis of 1090 patients with TBAD who underwent TEVAR. Patients were grouped into tertiles according to log2-transformed EASIX. Logistic and Cox regression, win ratio, landmark analysis, propensity score matching, and receiver operating characteristic analyses were performed to evaluate the prognostic and predictive value of EASIX for short-term and long-term outcomes. Results: A total of 172 (15.8%) patients experienced short-term adverse events, and 206 (18.9%) patients died during a median follow-up of 7.04 years. Logistic regression analyses indicated that greater EASIX levels were associated with an increased risk of composite end points (odds ratio, 1.69; 95% CI, 1.37-2.08; Conclusions: EASIX was associated with both short-term and long-term outcomes in patients with TBAD after TEVAR. Therefore, EASIX may serve as a supplementary indicator for risk stratification before intervention.