ArticleFrontiers in toxicology2026
A systems-level integration of liver-kidney transcriptomics and genome-scale metabolic models reveals organ-specific injury mechanisms.
Article in Frontiers in toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The liver and kidneys are the primary organs that clear chemicals from the body, yet they often exhibit different pathological responses to the same systemic exposure. While high-throughput transcriptomics (HTT) can map broad molecular perturbations, identifying the differential mechanisms that govern organ-specific injury remains a challenge. To address this knowledge gap, we investigated the dose-dependent effects of three peroxisome proliferator-activated receptor alpha agonists-coumarin, fenofibrate, and perfluorooctanoic acid (PFOA)-on liver and kidney metabolism to understand the organ-specific mechanisms of toxicity. We used HTT data from 5-day
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