Evidence map›Paper›PMID 42473762›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2026

Geometry-Programmable Living Immunomaterials for Spatial Control of Innate Immune Signaling.

Haoyuan Xu, Xiangbowen Jin, Xing Lu, Yufan Ling, Di Fan, Houyu Wang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Haoyuan XuMicrobial Sensing and Imaging Analysis Laboratory, Institute of Functional Nano & Soft Materials & Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC), Soochow University, Suzhou, Jiangsu, P. R. China.
Xiangbowen JinMicrobial Sensing and Imaging Analysis Laboratory, Institute of Functional Nano & Soft Materials & Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC), Soochow University, Suzhou, Jiangsu, P. R. China.
Xing LuMicrobial Sensing and Imaging Analysis Laboratory, Institute of Functional Nano & Soft Materials & Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC), Soochow University, Suzhou, Jiangsu, P. R. China.
Yufan LingState Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, P. R. China.
Di FanMicrobial Sensing and Imaging Analysis Laboratory, Institute of Functional Nano & Soft Materials & Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC), Soochow University, Suzhou, Jiangsu, P. R. China.
Houyu WangMicrobial Sensing and Imaging Analysis Laboratory, Institute of Functional Nano & Soft Materials & Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC), Soochow University, Suzhou, Jiangsu, P. R. China.ORCID https://orcid.org/0000-0002-5134-9881

Funding

111 ProjectCollaborative Innovation Center of Suzhou Nano Science and TechnologyNational Key Research and Development Program of China 2023YFB3208200Natural Science Foundation of Jiangsu Province of China BK20240766Priority Academic Program Development of Jiangsu Higher Education InstitutionsSuzhou Applied Basic Research (Healthcare) Science and Technology Innovation Program SYW2024068
6 · The paper itself

Abstract

Spatial organization of immune ligands critically regulates cGAS-STING signaling by controling the nanoscale geometry that drives cooperative cGAS assembly and catalytic activity. Here we engineer geometry-programmable DNA origami that precisely encodes double-stranded DNA (dsDNA) valency and spacing to promote cooperative cGAS clustering and STING activation. Systematic architectural modulation identifies an optimal configuration within tested ranges, in which 60-bp dsDNA ligands arranged with ∼16.3 nm periodicity induce approximately twofold stronger STING signaling than free dsDNA counterparts. We further integrate these origamis with the probiotic Escherichia coli Nissle 1917 via transporter-mediated surface anchoring, forming a living immunomaterial interface for localized ligand presentation in colorectal tumors. In microsatellite-stable colorectal cancer models, this biohybrid system drives robust intratumoral STING activation, promotes T-cell-inflamed immune remodeling, and suppresses tumor growth by ∼83.5% relative to controls. This work establishes a geometry-programmable living immunomaterial translating nanoscale architectural design into spatially confined innate immune signaling.

Indexed as

DNAImmunity, InnateSignal TransductionAnimalsCell Line, TumorcGAS-STING Signaling PathwayColorectal NeoplasmsDNA NanostructuresEscherichia coliHumansMembrane ProteinsMiceSTING ProteinDNAMembrane ProteinsSTING Proteincolorectal cancerDNA origamimaltodextrin transportersprobioticsSTING activation

Identifiers

PMID42473762
PMCPMC13508714

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.