Evidence map›Paper›PMID 42473871›Full record

ReviewAlzheimer's & dementia : the journal of the Alzheimer's Association2026

A gradual and sustainable approach to diagnosing sleep and circadian disturbances in dementia.

Biancamaria Guarnieri, Domeniko Hoxhaj, Francesca Buracchi Torresi, Dario Arnaldi, Enrica Bonanni, Matteo Carpi, Riccardo Cremascoli, Claudio Liguori, Gemma Lombardi, Greta Mainieri and 4 more

Abstract readReview
In one paragraph

Review in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Biancamaria GuarnieriCenter of Sleep Medicine, Department of Neurology, Villa Serena Hospital, Città S. Angelo, Pescara, Italy.ORCID https://orcid.org/0000-0003-1973-8796
Domeniko HoxhajDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.ORCID https://orcid.org/0009-0006-3561-3896
Francesca Buracchi TorresiDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.
Dario ArnaldiDepartment of Neuroscience (DINOGMI), University of Genoa, Genoa, Italy.
Enrica BonanniDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.
Matteo CarpiDepartment of Human Neurosciences, Sapienza University of Rome, Rome, Italy.
Riccardo CremascoliIRCCS, Istituto Auxologico Italiano, Auxologico Villa Caramora, Verbania, Italy.
Claudio LiguoriSleep Medicine Center, Neurology Unit, University Hospital of Rome Tor Vergata, Rome, Italy.
Gemma LombardiNeurology 8-Dementias and degenerative diseases of CNS Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy.
Greta MainieriIRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
Federica ProviniIRCCS Istituto delle Scienze Neurologiche di Bologna, Bologna, Italy.
Rosalia SilvestriSleep Medicine Center, Department of Clinical and Experimental Medicine, University Hospital "G. Martino", University of Messina, Messina, Italy.
Monica PulighedduDepartment of Medical Sciences and Public Health, University of Cagliari, Cagliari, Italy.
Michelangelo Maestri TassoniDepartment of Clinical and Experimental Medicine, Neurology Unit, University of Pisa, Pisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence linking sleep and circadian disruptions to the course of dementias, particularly Alzheimer's disease, has expanded. Such alterations are detectable from preclinical stages and parallel the disease progression. Assessing and managing sleep and circadian disturbances in patients with dementia remains challenging. New technologies are emerging, but their validation is still pending. We prepared a clinical review outlining a stepped-care, gradual, and sustainable approach aimed at achieving the most accurate possible diagnosis of different sleep disturbances. This review encompasses diagnostic methods ranging from questionnaires to instrumental assessments, progressing from simpler to more complex techniques including biological evaluations of circadian rhythm alterations. This work reflects a scientific consensus within the "Sleep" study group of the Italian Association for Dementia (SINdem), supported by certified sleep specialists. The document aims to support clinicians in adopting a tailored approach to the evaluation of sleep disturbances in dementia offering a dynamic framework balancing complexity and feasibility.

Indexed as

Chronobiology DisordersDementiaSleep Wake DisordersCircadian RhythmHumansPolysomnographySurveys and QuestionnairesactigraphyAlzheimer's diseasebiological assessment of circadian disturbancesdementiahome sleep apnea testingpolysomnographyquestionnairessleep and circadian rhythm disturbances diagnosisstepped care approach

Identifiers

PMID42473871
PMCPMC13382783

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.