SynthesisCornea2026
Patient-Reported Outcomes in Infectious Keratitis: A Systematic Review.
Synthesis in Cornea, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeInfectious keratitis has a profound impact on patients quality of life (QoL). Patient-reported outcome measures (PROMs) provide an invaluable method to capture subjective patient experiences and support practitioners in health care delivery. The primary and secondary objectives of this review were to systematically evaluate PROM tools used in infectious keratitis and evaluate the quality and content of PROMs in use for infectious keratitis.
methodsThe protocol implemented for review was published in PROSPERO (CRD42023464686). A literature review was performed in PubMed, MEDLINE OVID, Embase OVID, Cochrane, Scopus, Web of Science, and PsycINFO in October 2023. Full-length studies, published in English, featuring named and externally validated PROMs which were used to evaluate QoL outcomes of patients with infectious keratitis, were included. Nonvalidated PROMs used in patients with infectious keratitis were excluded. Studies including but not explicitly defining corneal pathologies were also excluded. Psychometric quality, validity, and risk of bias of each PROM were assessed using previously validated criteria.
resultsEight studies evaluated PROMS in infectious keratitis, with 8 different PROMs (1 generic, 7 ophthalmic but not keratitis-specific) used. Patients with infectious keratitis demonstrated impaired QoL in all PROMs, domains representing vision and visual function most impaired. Dependence, mobility, and mental and emotional state were also affected. Only 1 paper (13%) used psychometric analysis to validate the PROMs before use.
conclusionsInfectious keratitis has a negative impact on patient's QoL, across multiple domains. A variety of PROMS have been used to assess QoL in keratitis with most awaiting validation for infectious keratitis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.