Evidence map›Paper›PMID 42474451›Full record

ArticleeLife2026

Cluster size determines internal structure of transcription factories in human cells.

Massimiliano Semeraro, Giuseppe Negro, Giada Forte, Antonio Suma, Giuseppe Gonnella, Peter Cook, Davide Marenduzzo

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Massimiliano Semeraro *Dipartimento Interateneo di Fisica, Università degli Studi di Bari and INFN, Sezione di Bari, Bari, Italy.
Giuseppe Negro *SUPA School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.ORCID https://orcid.org/0000-0003-1755-7051
Giada ForteSUPA School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.ORCID https://orcid.org/0000-0001-9939-4465
Antonio SumaDipartimento Interateneo di Fisica, Università degli Studi di Bari and INFN, Sezione di Bari, Bari, Italy.ORCID https://orcid.org/0000-0002-5049-9255
Giuseppe GonnellaDipartimento Interateneo di Fisica, Università degli Studi di Bari and INFN, Sezione di Bari, Bari, Italy.
Peter CookSir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.
Davide MarenduzzoSUPA School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom.

Funding

Leverhulme Trust ECF-2024-221Wellcome TrustWellcome Trust 223097/Z/21/Z
6 · The paper itself

Abstract

Transcription is a fundamental cellular process and the first step of gene expression. In human cells, it depends on the binding to chromatin of various proteins, including RNA polymerases and numerous transcription factors (TFs). Observations indicate that these proteins tend to form macromolecular clusters, known as

Indexed as

ChromatinTranscription FactorsTranscription, GeneticHumansProtein BindingChromatinTranscription Factorschromatinchromosomesgene expressionhumanmixed and demixed factoriesphysics of living systemspolymer modelstranscription factoriestranscription factors

Identifiers

PMID42474451
PMCPMC13384497

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.