Evidence map›Paper›PMID 42474456›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

A Supramolecular Thermal Switch for Precision Pyroptosis via Host-Guest Recognition and Electrostatic Interactions.

Dan Wu, Jie Zhou, Yibin Cao, Kunmin Ping, Borui Zhao, Yanrong Yang, Chunyang Yu, Xinyang Yu, Shaolong Qi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Dan WuState Key Laboratory of Advanced Separation Membrane Materials, Zhejiang Key Laboratory of Advanced Polymer Materials Modification and Application Technology, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, P. R. China.
Jie ZhouState Key Laboratory of Advanced Separation Membrane Materials, Zhejiang Key Laboratory of Advanced Polymer Materials Modification and Application Technology, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, P. R. China.
Yibin CaoState Key Laboratory of Advanced Separation Membrane Materials, Zhejiang Key Laboratory of Advanced Polymer Materials Modification and Application Technology, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, P. R. China.
Kunmin PingState Key Laboratory of Advanced Separation Membrane Materials, Zhejiang Key Laboratory of Advanced Polymer Materials Modification and Application Technology, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, P. R. China.
Borui ZhaoState Key Laboratory of Advanced Separation Membrane Materials, Zhejiang Key Laboratory of Advanced Polymer Materials Modification and Application Technology, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, P. R. China.
Yanrong YangState Key Laboratory of Advanced Separation Membrane Materials, Zhejiang Key Laboratory of Advanced Polymer Materials Modification and Application Technology, College of Materials Science and Engineering, Zhejiang University of Technology, Hangzhou, P. R. China.
Chunyang YuState Key Laboratory of Synergistic Chem-Bio Synthesis, School of Chemistry and Chemical Engineering, Shanghai Key Laboratory of Electrical Insulation and Thermal Aging, Shanghai Jiao Tong University, Shanghai, P. R. China.ORCID https://orcid.org/0000-0003-1175-8362
Xinyang YuDepartment of Chemistry, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, P. R. China.
Shaolong QiDepartment of Chemistry, Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology, Tsinghua University, Beijing, P. R. China.ORCID https://orcid.org/0000-0003-2744-5387

Funding

Beijing Municipal Science & Technology Commission Z231100007223007China Postdoctoral Science Foundation 2023M733360National Key R&D Program of China 2023YFC3403102National Key R&D Program of China 2023YFE0204900National Natural Science Foundation of China 22175107National Natural Science Foundation of China 22305140National Natural Science Foundation of China 22305220
6 · The paper itself

Abstract

Cytomembrane-puncturing gasdermin (GSDM)-mediated pyroptosis activates antitumor immunity through the release of immunogenic cellular contents and proinflammatory cytokines. However, programmable and precise pyroptosis remains challenging due to the rigidity, inefficiency, and systemic toxicity of conventional inducers. Herein, a supramolecular thermal switch is engineered to enable precision pyroptosis induction. Triiodide ions (I

Indexed as

Ca2+ overloadelectrostatic interactionshost–guest complexpyroptosissupramolecular chemistry

Identifiers

PMID42474456
PMCPMC13384033

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.