Evidence map›Paper›PMID 42474458›Full record

ArticleHippocampus2026

Myosin IIB Maintains Long-Term Memory.

Mateus Oliveira Silva, Lucas Aschidamini Marcondes, Paula Lunardi, Bruno Popik, Rossana Rosa Porto, Marina da Silva Medeiros, Lucas de Oliveira Alvares

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Hippocampus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Mateus Oliveira SilvaLaboratório de Neurobiologia da Memória, Departamento de Biofísica, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.ORCID https://orcid.org/0000-0003-3431-7797
Lucas Aschidamini MarcondesLaboratório de Neurobiologia da Memória, Departamento de Biofísica, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.ORCID https://orcid.org/0000-0002-6316-9781
Paula LunardiLaboratório de Neurobiologia da Memória, Departamento de Biofísica, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.ORCID https://orcid.org/0000-0001-7232-9073
Bruno PopikLaboratório de Neurobiologia da Memória, Departamento de Biofísica, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.ORCID https://orcid.org/0000-0002-0385-2749
Rossana Rosa PortoLaboratório de Neurobiologia da Memória, Departamento de Biofísica, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Marina da Silva MedeirosLaboratório de Neurobiologia da Memória, Departamento de Biofísica, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Lucas de Oliveira AlvaresLaboratório de Neurobiologia da Memória, Departamento de Biofísica, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 440413/2014-1Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul 21/2551-0001971-9
6 · The paper itself

Abstract

Synaptic plasticity and memory are intrinsically linked to the dynamics of dendritic spines. The protein myosin IIB is central to the morphology and physiology of dendritic spines and thereby regulates synaptic plasticity. In this study, we used specific inhibitors of myosin IIB, blebbistatin (Blebb) and para-nitro-blebbistatin (p-N-Blebb), to assess its role in memory. We found that inhibiting myosin IIB in the hippocampus impairs long-term fear memory consolidation, but not short-term memory, and that pretest blockade hinders memory retrieval. Remarkably, we observed that blocking myosin IIB activity in the hippocampus, amygdala, or insular cortex 24 h after training impairs distinct consolidated memories, suggesting that myosin IIB plays an essential role in memory maintenance. Our results show that myosin IIB activity is crucial not only for memory formation and expression but also for memory storage, likely by preserving dendritic spines after learning.

Indexed as

HippocampusMemory, Long-TermNonmuscle Myosin Type IIBAmygdalaAnimalsDendritic SpinesFearHeterocyclic Compounds, 4 or More RingsInsular CortexMemory ConsolidationMemory, Short-TermNeuronal PlasticityblebbistatinHeterocyclic Compounds, 4 or More RingsNonmuscle Myosin Type IIBblebbistatindendritic spinesmemory maintenancemyosin IIBsynaptic plasticity

Identifiers

PMID42474458
PMCPMC13384089

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.