Evidence map›Paper›PMID 42474763›Full record

SynthesisEuropean journal of pediatrics2026

Recreational nitrous oxide-related myeloneuropathy in adolescents: a multicenter retrospective case series and systematic literature review.

Lital Cohen-Vig, Noy Hota, Oded Scheuerman, Tamar Steinberg, Maha Zeidan, Jacob Genizi, Eran Rom, Elena Kogan, Sharon Aharoni

Abstract readSystematic ReviewMulticenter Study
PubMed Publisher
In one paragraph

Synthesis in European journal of pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lital Cohen-Vig *Institute of Pediatric Neurology, Schneider Children's Medical Center of Israel, Petach Tikva, 49420235, Israel. lital.co@gmail.com.ORCID http://orcid.org/0000-0002-4750-4666
Noy Hota *Gray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.
Oded ScheuermanGray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.
Tamar SteinbergInstitute of Pediatric Neurology, Schneider Children's Medical Center of Israel, Petach Tikva, 49420235, Israel.
Maha ZeidanPediatric Department, Bnai Zion Medical Center, Haifa, 31048, Israel.
Jacob GeniziPediatric Department, Bnai Zion Medical Center, Haifa, 31048, Israel.
Eran RomGray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.
Elena KoganGray Faculty of Medical & Health Sciences, Tel Aviv University, Tel Aviv, 6997801, Israel.
Sharon AharoniInstitute of Pediatric Neurology, Schneider Children's Medical Center of Israel, Petach Tikva, 49420235, Israel.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nitrous oxide (N

conclusionN WHAT IS KNOWN: • Recreational N2O use is common and may cause myeloneuropathy, primarily due to B12 dysfunction. Homocysteine and methyl-malonic acid levels are better biomarkers of B12 dysfunction. • Information on unique features of neurological complications in adolescents is sparse. WHAT IS NEW: • Chronic N2O use in adolescents is predominantly associated with sensory symptoms; a potential association with elevated intracranial pressure is suggested. • Subclinical B12 deficiency may serve as a predisposing factor for neurological complications.

Indexed as

Illicit DrugsNitrous OxideSpinal Cord DiseasesSubstance-Related DisordersAdolescentFemaleHumansMagnetic Resonance ImagingMaleNerve Conduction StudiesRetrospective StudiesVitamin B 12Vitamin B 12 DeficiencyIllicit DrugsNitrous OxideVitamin B 12Functional vitamin B12 deficiencyMyeloneuropathyRecreational N2O abuseSubacute combined cord degeneration

Identifiers

PMID42474763

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.