ArticleEBioMedicine2026
Single-cell sequencing reveals NK cell dysregulation during chronic HIV infection and identifies transitional NK cell cytotoxicity related to HIV reservoir decay.
Article in EBioMedicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNatural killer (NK) cells, as an integral component of the innate immune system, assume a pivotal role in combating viral infections. Our understanding of how human immunodeficiency virus (HIV) infection affects NK cell heterogeneity remains limited.
methodsWe conducted single-cell RNA sequencing (scRNA-seq) on peripheral blood NK cells from five healthy controls and seventeen male people living with HIV (PLWH), both before and after antiretroviral therapy (ART). Biological sex was extracted from medical records, and gender identity was not collected. O-link proteomic analysis was employed to quantify alterations in plasma inflammatory cytokines. Cell-associated HIV-DNA was measured in CD4
findingsAmong ten identified NK cell subsets, c7-Type I interferon (IFN)-responding cells were increased in untreated participants, correlating negatively with CD4
interpretationOur findings offer a comprehensive understanding of the cellular and molecular heterogeneity of NK cell immune response during HIV infection and offer insights for NK cell-based immunotherapies.
fundingSupported by grants from the National Natural Science Foundation of China (No. 82371766, 82572006, 82101837, and 82271857).
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.