Evidence map›Paper›PMID 42476990›Full record

ArticleNature communications2026

Hypertensive disorders of pregnancy contribute to developmental and metabolic multimorbidity in preterm infants.

Cuihong Yang, Ranran Shi, Jiao Yuan, Yanjie Ding, Hongli Geng, Huan Li, Lili Zhao, Jiahui Li, Mingming Zhao, Xiaoxue You and 5 more

Abstract readMulticenter Study
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Cuihong Yang *Department of Neonatology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.ORCID http://orcid.org/0000-0001-7833-3460
Ranran Shi *Department of Neonatology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China.
Jiao Yuan *Department of Neonatology, Yinchuan Women and Children Healthcare Hospital, Yinchuan, China.
Yanjie DingDepartment of Neonatology, Yantai Yuhuangding Hospital, Yantai, China.
Hongli GengDepartment of Neonatology, Zibo Maternal and Child Health Hospital, Zibo, China.
Huan LiDepartment of Neonatology, Hebei PetroChina Central Hospital, Langfang, China.
Lili ZhaoDepartment of Neonatology, Liaocheng People's Hospital, Liaocheng, China.
Jiahui LiDepartment of Neonatology, The First Affliated Hospital of Shandong First Medical University, Jinan, China.
Mingming ZhaoDepartment of Neonatology, W.F. Maternal and Child Health Hospital, Weifang, China.
Xiaoxue YouDepartment of Neonatology, Women and Children's Healthcare Hospital of Linyi, Linyi, China.
Yongfeng JiaDepartment of Neonatology, Shangluo Central Hospital, Shangluo, China.
Ming ZhangShandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China.
Wenwen ZhangJinan Maternity and Child Care Hospital affiliated to Shandong First Medical University, Jinan, China.
Jie GuDepartment of Neonatology, Yinchuan Women and Children Healthcare Hospital, Yinchuan, China.
Yonghui YuDepartment of Neonatology, Shandong Provincial Hospital affiliated to Shandong First Medical University, Jinan, China. alice20402@126.com.ORCID http://orcid.org/0000-0001-7699-7482

Funding

National Natural Science Foundation of China (National Science Foundation of China) 82470824Natural Science Foundation of Ningxia Province (Ningxia Provincial Natural Science Foundation) 2024AAC03804Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation) ZR2023MH175Natural Science Foundation of Shandong Province (Shandong Provincial Natural Science Foundation) ZR2024QH380
6 · The paper itself

Abstract

Preterm birth poses a global health challenge, frequently resulting in complex infant multimorbidity. While the adverse effects of maternal hypertensive disorders of pregnancy (HDP) on offspring are well recognized, their specific impact on distinct multimorbidity patterns in very preterm infants remains underexplored. In this multicenter cohort study, we utilize the Sino-northern Neonatal Network (SNN) database to systematically characterize these profiles. Here we show distinct patterns, including extrauterine growth restriction (EUGR) complicated by parenteral nutrition-associated cholestasis (EUGR-PNAC), congenital hypothyroidism (EUGR-CH), retinopathy of prematurity (EUGR-ROP), and bronchopulmonary dysplasia (EUGR-BPD). Notably, maternal HDP significantly increases the risk of developing these specific patterns. By elucidating these clinical consequences, our study advances the current understanding of the impact of adverse intrauterine exposures on offspring health. Ultimately, these insights highlight the critical need for multidisciplinary screening and management in this high-risk population, providing a crucial foundation for improving long-term neonatal outcomes.

Indexed as

Hypertension, Pregnancy-InducedInfant, PrematureBronchopulmonary DysplasiaCholestasisCohort StudiesFemaleFetal Growth RetardationHumansInfant, NewbornMaleParenteral NutritionPregnancyPremature Birth

Identifiers

PMID42476990
PMCPMC13500844

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.