ArticleJournal of perinatology : official journal of the California Perinatal Association2026
Targeted neonatal echocardiography-guided management of high flow cerebral vascular malformations: Impact of a multidisciplinary neurohemodynamics team.
Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Authors and funding
5 authors.
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Abstract
BACKGROUND AND
objectiveHigh-flow cerebral vascular malformations (HFCVM) are rare, life-threatening anomalies causing severe neonatal cardiorespiratory compromise. Targeted neonatal echocardiography (TNE) enables detailed hemodynamic assessment to guide stabilization and embolization timing. We evaluated a multidisciplinary, TNE-guided protocol to optimize individualized care and shorten shunting duration.
methodsSingle-center case series of five neonates with HFCVM admitted to a Level IV NICU (June 2022-June 2025). The protocol incorporated serial TNE for prenatal diagnosis, pre-/post-embolization care, and intra-procedural monitoring. TNE categorized cardiovascular phenotypes, guided embolization timing, and monitored cardiac function.
resultsFive neonates with HFCVM were managed using this protocol. Median number of embolizations per neonate were 2 (2.0-2.5). Four patients exhibited flow-mediated physiology with high cardiac output and ductal-dependent systemic perfusion. Four patients survived to discharge. One patient experienced a fatal intracranial hemorrhage.
conclusionA physiology-driven, TNE-guided approach for neonatal HFCVM is feasible and supports tailored hemodynamic management and staged embolization. Prospective multicenter validation is warranted.
Identifiers
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Registered trials
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