Evidence map›Paper›PMID 42477140›Full record

ArticleNature cell biology2026

Mitochondrial-derived vesicles drive budding-type fission of damaged lysosomes.

Yuanchun Luo, Jianglong Yu, Zhuofan Li, Wanning Li, Le Jiang, Chen Huang, Zhouyi Rong, Long Lin, Yueguang Rong, Chaojun Yan and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature cell biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Yuanchun Luo *Department of Pathology, School of Basic Medicine, Institute of Pathology, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.
Jianglong Yu *Department of Pathology, School of Basic Medicine, Institute of Pathology, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0009-0004-3071-6955
Zhuofan LiDepartment of Pathology, School of Basic Medicine, Institute of Pathology, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.
Wanning LiDepartment of Pathology, School of Basic Medicine, Institute of Pathology, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.
Le JiangDepartment of Pathology, School of Basic Medicine, Institute of Pathology, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.
Chen HuangCollege of Life Sciences, Frontier Science Center for Immunology and Metabolism, Wuhan University, Wuhan, China.ORCID http://orcid.org/0009-0004-1500-0545
Zhouyi RongDepartment of Pathology, School of Basic Medicine, Institute of Pathology, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0000-0003-4849-1278
Long LinDepartment of Pathology, School of Basic Medicine, Institute of Pathology, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.
Yueguang RongDepartment of Pathology, School of Basic Medicine, Institute of Pathology, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0000-0001-6661-9664
Chaojun YanNational '111' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, China.
Zhishui ChenDepartment of Pathology, School of Basic Medicine, Institute of Pathology, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.
Jingfeng TangNational '111' Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Cooperative Innovation Center of Industrial Fermentation (Ministry of Education and Hubei Province), Hubei Key Laboratory of Industrial Microbiology, Hubei University of Technology, Wuhan, China.ORCID http://orcid.org/0000-0002-5524-4518
He HeDepartment of Pathology, School of Basic Medicine, Institute of Pathology, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.
Anbing ShiDepartment of Pathology, School of Basic Medicine, Institute of Pathology, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China.ORCID http://orcid.org/0000-0003-1128-2026
Zhiyin SongDepartment of Pathology, School of Basic Medicine, Institute of Pathology, Institute of Organ Transplantation, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and Treatment of Severe Zoonotic Infectious Diseases, Huazhong University of Science and Technology, Wuhan, China. songzy@hust.edu.cn.ORCID http://orcid.org/0000-0002-5003-081X

Funding

National Natural Science Foundation of China (National Science Foundation of China) U25A20650
6 · The paper itself

Abstract

Lysosomes are central degradative organelles essential for cellular homeostasis, yet the mechanisms that maintain their integrity and function under stress remain incompletely understood. Here we identify a previously unrecognized lysosomal renewal process, termed budding-type fission (B-fission), which restores lysosomal function during hypoxia-reoxygenation stress. During B-fission, damaged lysosomes generate membrane buds that undergo scission to form small, fully functional lysosomes, independently of autophagic lysosome reformation. Mechanistically, mitochondrial-derived vesicles (MDVs) deliver the fission adaptor MFF to lysosomes, where MFF recruits the dynamin-related GTPase DRP1 to drive membrane scission. MIRO2 promotes the formation of MFF

Indexed as

LysosomesMitochondriaMitochondrial DynamicsAdaptor Proteins, Signal TransducingAMP-Activated Protein KinasesAnimalsAutophagyCell HypoxiaDynaminsGTP PhosphohydrolasesHeLa CellsHumansMembrane ProteinsMiceMitochondrial ProteinsAdaptor Proteins, Signal TransducingAMP-Activated Protein KinasesDNM1L protein, humanDynaminsGTP PhosphohydrolasesMembrane ProteinsMitochondrial Proteins

Identifiers

PMID42477140

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.