ArticlePediatric research2026
The associations between systemic immune-inflammation index and IgE in children with allergic rhinitis: a case-control study.
Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Parental Experiences and Psychological Support Needs Following Fetal Diagnosis of Congenital Heart Disease: A Qualitative Study.Pediatric cardiology · 2026Article
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe prevalence of allergic rhinitis (AR) in children is increasing worldwide, driving the growing demand for diagnostic biomarkers to improve clinical practice. Peripheral blood inflammatory indices, as easily accessible and measurable parameters, may offer valuable insights into AR. This study aimed to evaluate the association between peripheral blood inflammatory indices and AR in children.
methodsWe analyzed peripheral blood inflammatory indices in 1,028 children diagnosed with or without AR from Guangdong Women and Children Hospital. Logistic regression and spearman correlation analysis were employed to investigate the association between these indices and AR. Receiver operating characteristic (ROC) curves were used to assess these indices in predicting AR.
resultsThe Systemic Immune-Inflammation Index (SII) values were significantly higher in AR group. The highest quartile of SII was associated with an increased risk of AR (odds ratio (OR) = 4.86) compared to the lowest quartile. In AR children, SII was positively correlated with IgE (r = 0.324, p = 0.002). The IgE × SII index showed the greatest AUC in predicting high-SII/low-EOS AR subtype (AUC: 0.953).
conclusionsSII was positively associated with IgE in AR children, and the IgE × SII index demonstrated strong predictive value for AR with low eosinophils count. IMPACT: SII is elevated in children with AR. SII is positively correlated with IgE but not EOS or %EOS in AR children. The combined index SII × IgE exhibited an improved predictive value for high-inflammation/high-atopic AR.
Identifiers
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Registered trials
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