ArticleNaunyn-Schmiedeberg's archives of pharmacology2026
Hyaluronidase attenuates radiation-induced skin fibrosis through extracellular matrix remodeling and suppression of inflammatory-profibrotic signaling.
Article in Naunyn-Schmiedeberg's archives of pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Radiation-induced fibrosis is a progressive late effect of radiotherapy characterized by chronic inflammation, extracellular matrix accumulation, and functional tissue contracture. We evaluated whether delayed local hyaluronidase treatment attenuates established radiation-induced skin fibrosis in mice. Male C57BL/6 mice underwent localized hind-limb irradiation (60 Gy total, 30 Gy × 2). After a 28-day fibrosis-development period, irradiated mice received saline, topical 0.1% triamcinolone acetonide, or hyaluronidase every 2 days for 2 weeks and non-irradiated mice served as normal controls. Outcomes included hind-limb mobility, skin thickness, collagen burden, inflammatory-cell infiltration, nitrite/NO level, cytokines, and fibrosis-related gene expression. At day 56 after treatment initiation, hyaluronidase increased hind-limb passive extension from 2.19 ± 0.37 cm in irradiated controls to 3.53 ± 0.04 cm and increased joint angle from 81.40 ± 9.62° to 102.00 ± 6.09°. Total skin thickness decreased from 472.3 ± 50.4 μm to 308.8 ± 18.7 μm, collagen area from 37.8 ± 4.7% to 20.9 ± 1.7%, hydroxyproline content from 91.6 ± 3.8 to 17.6 ± 1.6 μg/mg, inflammatory-cell count from 88.5 ± 11.8 to 13.6 ± 1.2 cells/HPF, and nitrite/NO level from 46.9 ± 5.8 to 27.6 ± 2.0 μM. Hyaluronidase also reduced TNF-α, IL-6, MCP-1, and IL-1β levels and downregulated Tgfb1, Acta2, Col1a1, Il4, Il13, and Il31 expression. Local hyaluronidase treatment attenuated functional, histologic, inflammatory, and molecular features of radiation-induced skin fibrosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.