Evidence map›Paper›PMID 42477315›Full record

ArticleCell discovery2026

GV-971 remodels the gut microbiota-bile acid-FXR axis to ameliorate obesity and metabolic dysfunction.

Na Zhang, Xinyu Ye, Kai Wang, Yameng Hu, Zixi Wang, Lichun Huang, Xi Chen, Ding Yan, Wen Fu, Qian Xue and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell discovery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Na ZhangGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangdong, Guangzhou, China.
Xinyu YeGuangdong Provincial Key Laboratory of Protein Modification and Disease, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, School of Basic Medical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangdong, Guangzhou, China.
Kai WangGuangdong Provincial Key Laboratory of Protein Modification and Disease, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, School of Basic Medical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangdong, Guangzhou, China.
Yameng HuGuangdong Provincial Key Laboratory of Protein Modification and Disease, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, School of Basic Medical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangdong, Guangzhou, China.
Zixi WangGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangdong, Guangzhou, China.
Lichun HuangGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangdong, Guangzhou, China.
Xi ChenGuangdong Provincial Key Laboratory of Protein Modification and Disease, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, School of Basic Medical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangdong, Guangzhou, China.
Ding YanGuangdong Provincial Key Laboratory of Protein Modification and Disease, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, School of Basic Medical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangdong, Guangzhou, China.
Wen FuGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangdong, Guangzhou, China.
Qian XueGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangdong, Guangzhou, China.
Shihao SunGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangdong, Guangzhou, China.
Yihan XuGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangdong, Guangzhou, China.ORCID http://orcid.org/0009-0004-6045-647X
Daolin TangDepartment of Surgery, UT Southwestern Medical Center, Dallas, TX, USA.ORCID http://orcid.org/0000-0002-1903-6180
Xin ChenGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangdong, Guangzhou, China. chenxin@gzhmu.edu.cn.ORCID http://orcid.org/0000-0003-3668-4830
Li ZhouGuangdong Provincial Key Laboratory of Protein Modification and Disease, Key Laboratory of Biological Targeting Diagnosis, Therapy and Rehabilitation of Guangdong Higher Education Institutes, School of Basic Medical Sciences and The Fifth Affiliated Hospital, Guangzhou Medical University, Guangdong, Guangzhou, China. zhouli@gzhmu.edu.cn.
Jinbao LiuGuangzhou Municipal and Guangdong Provincial Key Laboratory of Protein Modification and Disease, State Key Laboratory of Respiratory Disease, School of Basic Medical Sciences, Guangzhou Medical University, Guangdong, Guangzhou, China. jliu@gzhmu.edu.cn.ORCID http://orcid.org/0000-0003-2220-2407

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity and its associated metabolic complications represent a global health crisis, yet effective microbiota-targeted pharmacotherapies remain limited. Here, we report that GV-971 (sodium oligomannate), a marine-derived oligosaccharide originally developed for Alzheimer's disease, exerts potent anti-obesity and metabolic benefits by reprogramming gut microbial and host signaling networks. In high-fat diet-induced obese mice, GV-971 reduced adiposity, improved glucose homeostasis, and alleviated hepatic steatosis without affecting food intake. Multi-omics and causal intervention experiments revealed that GV-971 selectively decreased the abundance of Clostridium scindens, a keystone bacterium responsible for secondary bile acid synthesis. This decrease downregulated the expression of the baiF gene encoding 7α-hydroxysteroid dehydrogenase, leading to reduced intestinal deoxycholic acid (DCA) levels and inhibition of intestinal farnesoid X receptor (FXR) signaling. Restoration of C. scindens abundance, baiF expression, or DCA supplementation abrogated the metabolic benefits of GV-971, confirming the causal role of the C. scindens-DCA-FXR axis. Mechanistically, inhibition of intestinal FXR promoted thermogenic gene expression and white adipose tissue browning, thus enhancing systemic energy expenditure. These findings uncover a bacterium-metabolite-host signaling pathway underlying the effects of GV-971 and establish microbiota-directed FXR modulation as a promising therapeutic approach for obesity and metabolic disease.

Identifiers

PMID42477315
PMCPMC13385948

What Socratic holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.