ArticleCommunications biology2026
BubR1 TPR domain supports the mitotic checkpoint by promoting MCC formation and MCC-APC/C interaction.
Article in Communications biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
BubR1 is a key component of the mitotic checkpoint, a surveillance mechanism which ensures accurate chromosome segregation by facilitating the assembly of the mitotic checkpoint complex (MCC) and promoting its binding to the anaphase-promoting complex/cyclosome (APC/C). Although BubR1's role in the mitotic checkpoint has been extensively investigated, the function of its N-terminal tetratricopeptide repeat (TPR) domain remains poorly understood. In this study, we first establish the essential role of the BubR1 TPR domain in the mitotic checkpoint. Guided by the resolved cryo-EM structure of the MCC-APC/C complex, we identify and characterize several interactions between the BubR1 TPR domain and Mad2, Cdc20
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