ArticleBMC veterinary research2026
Chinese sacbrood virus destroys AcPPAN-copper homeostasis to evade phenoloxidase-based antiviral immunity in Apis cerana.
Article in BMC veterinary research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
backgroundThe Chinese sacbrood virus (CSBV) poses a serious threat to the Apis cerana, a major plant and crop pollinator. CSBV primarily infects larvae early in their development causing liquefaction of the larval epidermis preventing normal pupation. Bee larvae can resist viral infection through immune responses, with phenoloxidase (PO) being a key link between host cellular and humoral immunity. It is unknown whether host genes can modulate the PO cascade to affect viral replication. Herein, we performed RNA-Seq on CSBV-infected Apis cerana larvae and identify expression of the gene Peter Pan (AcPPAN), the gene had no significant effect on the development of larvae.
resultsAfter silencing AcPPAN, we found that the immune response of the larvae is suppressed and promoted CSBV replication. Subsequently, we fluorescently labeled copper ions in the larval hemolymph and found that AcPPAN responds to CSBV infection and is involved in limiting virus-induced copper accumulation within the hemolymph.
conclusionsOur findings indicate that CSBV promotes viral replication in larvae by suppressing AcPPAN expression, elevating hemolymph copper ion concentration, and inhibiting phenoloxidase-mediated antiviral immune responses.
Indexed as
Identifiers
42477720What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.