Evidence map›Paper›PMID 42477763›Full record

ArticleJournal of translational medicine2026

Adoptive transfer of VSIG4

Biao Duan, Jun Chen, Guan Liu, Jiacheng Lin, Shiyu Yang, Xiaoni Kong, Weifang Rong, Weifeng Tan

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Biao Duan *Hepatobiliary Surgery Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China.
Jun Chen *Baoshan Branch of Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200444, China.
Guan Liu *Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, 518055, China.
Jiacheng LinCentral Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China.
Shiyu YangBaoshan Branch of Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200444, China.
Xiaoni KongCentral Laboratory, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, 201203, China. kong_xiaoni@126.com.
Weifang RongDepartment of Gastroenterology, Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 201600, China. weifangrong@shsmu.edu.cn.
Weifeng TanHepatobiliary Surgery Center, Tongji Hospital, School of Medicine, Tongji University, Shanghai, 200092, China. twf1231@163.com.ORCID 0000-0002-9765-6377

Funding

National Natural Science Foundation of China 82170412Tongji Hospital Affiliated to Tongji University funds for scientific research RCQD2405
6 · The paper itself

Abstract

backgroundAcute liver injury (ALI) can rapidly progress to life-threatening acute liver failure. Liver transplantation remains the only definitive treatment, despite critical donor shortages. Macrophage-based therapies have shown promise in ALI but face challenges related to subset imprecision and limited humanized validation. VSIG4 is generally considered a marker of Kupffer cells; however, it is also expressed in monocyte-derived macrophages (MoMFs), and its role remains unclear during ALI.

methodsBy integrating single-cell RNA sequencing (scRNA-seq) data from human and mouse liver tissues with clinical ALI tissue samples, we elucidated the dynamic changes in VSIG4

resultsscRNA-seq revealed a previously underrecognized subpopulation of VSIG4 DISCUSSION: This study identifies VSIG4

Indexed as

AcetaminophenAdoptive TransferChemical and Drug Induced Liver InjuryChemokine CCL2InflammationMacrophagesOrganoidsReceptors, CCR2AnimalsChemotaxisDisease Models, AnimalHumansLiverMaleMiceMice, Inbred C57BLAcetaminophenChemokine CCL2Receptors, CCR2Acute liver injuryAdoptive cell therapyCCL2-CCR2 axisChemotaxisHuman liver organoidsVSIG4+ macrophages

Identifiers

PMID42477763
PMCPMC13386671

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.