ArticleThe Kaohsiung journal of medical sciences2026
FOXC1: A Key Transcription Factor of VSMC-Derived Foam Cell Formation in Atherosclerotic Plaque Instability.
Article in The Kaohsiung journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The instability of atherosclerotic plaques, particularly intraplaque hemorrhage (IPH), drives life-threatening cardiovascular events, a process in which vascular smooth muscle cell (VSMC)-derived foam cells play a significant role. We aim to identify key biomarkers associated with VSMC-derived foam cells and IPH by analyzing data from human IPH datasets and VSMC-derived foam cell datasets (GSE163154, GSE68021, GSE28829, and GSE43292). Weighted gene co-expression network analysis (WGCNA), differential expression analysis, and machine learning algorithms (LASSO and SVM-RFE) were employed to identify hub genes. The identified genes were validated in independent datasets and in experimental models, including oxidized low-density lipoprotein-stimulated VSMCs and atherosclerotic aortic tissues of high-fat diet-fed ApoE
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