Evidence map›Paper›PMID 42477895›Full record

ArticlePhysiological reports2026

Effect of complement 3/5 knockout on renal proteomics landscape after ischemia and reperfusion injury in rats.

Dinesh Bhattarai, Amod Sharma, Madison McGraw, Se-Ran Jun, Neelam Joshi, Neriman Gokden, Samuel Mackintosh, Nirmala Parajuli

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Physiological reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Dinesh BhattaraiDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Science, Little Rock, Arkansas, USA.ORCID https://orcid.org/0000-0002-9653-4044
Amod SharmaDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Science, Little Rock, Arkansas, USA.ORCID https://orcid.org/0000-0002-2860-7790
Madison McGrawDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Science, Little Rock, Arkansas, USA.ORCID https://orcid.org/0009-0008-5602-1982
Se-Ran JunDepartment of Medical Informatics, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Neelam JoshiDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Science, Little Rock, Arkansas, USA.
Neriman GokdenDepartment of Pathology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Samuel MackintoshDepartment of Biochemistry and Molecular Biology, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Nirmala ParajuliDepartment of Pharmacology and Toxicology, University of Arkansas for Medical Science, Little Rock, Arkansas, USA.ORCID https://orcid.org/0000-0003-3994-5338

Funding

Targeting heat shock protein 72 to improve renal function after transplantationR01DK123264 · NIDDK · UNIV OF ARKANSAS FOR MED SCIS · PI PARAJULI, NIRMALA · 2021 to 2025
$2.4M
Department of Surgery, Division of Transplant Surgery, (Bhattarai), University of Utah School of MedicineNIDDK NIH HHS R01 DK123264University of Arkansas for Medical Sciences (UAMS)
6 · The paper itself

Abstract

Ischemia-reperfusion injury (IRI) is a major driver of acute kidney injury and development of chronic kidney disease. Although complement activation worsens IRI, the roles of upstream (C3) versus downstream (C5) components remain unclear. Renal IRI was surgically induced in C3 knockout (C3

Indexed as

Acute Kidney InjuryComplement C3Complement C5KidneyProteomeReperfusion InjuryAnimalsMaleProteomicsRatsRats, Inbred LewComplement C3Complement C5Proteomeacute kidney injurycomplement C3complement C5ischemia–reperfusion injurykidney transplantationproteomics

Identifiers

PMID42477895
PMCPMC13385224

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.