Evidence map›Paper›PMID 42478598›Full record

Trial reportAlzheimer's & dementia : the journal of the Alzheimer's Association2026

A phase-II randomized controlled pilot study of nicotinamide riboside supplementation in older adults with amnestic mild cognitive impairment.

Christopher R Martens, Kevin P Decker, Theodore M DeConne, Faria Sanjana, Fiona Horvat, Nicholas A Rizzi, Catherine Awad, Elizabeth Habash, Joshua C Hobson, Mary K Kramer and 7 more

Abstract readRandomized Controlled TrialClinical Trial, Phase II
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Christopher R MartensDepartment of Kinesiology & Applied Physiology, University of Delaware, Newark, Delaware, USA.ORCID https://orcid.org/0000-0003-0578-2948
Kevin P DeckerDepartment of Kinesiology & Applied Physiology, University of Delaware, Newark, Delaware, USA.
Theodore M DeConneDepartment of Kinesiology & Applied Physiology, University of Delaware, Newark, Delaware, USA.
Faria SanjanaDepartment of Kinesiology & Applied Physiology, University of Delaware, Newark, Delaware, USA.
Fiona HorvatDepartment of Kinesiology & Applied Physiology, University of Delaware, Newark, Delaware, USA.
Nicholas A RizziDepartment of Kinesiology & Applied Physiology, University of Delaware, Newark, Delaware, USA.
Catherine AwadDepartment of Kinesiology & Applied Physiology, University of Delaware, Newark, Delaware, USA.
Elizabeth HabashDepartment of Kinesiology & Applied Physiology, University of Delaware, Newark, Delaware, USA.
Joshua C HobsonDepartment of Kinesiology & Applied Physiology, University of Delaware, Newark, Delaware, USA.
Mary K KramerDepartment of Biomedical Engineering, University of Delaware, Newark, Delaware, USA.
Michael L ArmstrongDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Denver, Colorado, USA.
Nichole ReisdorphDepartment of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, Denver, Colorado, USA.
Ryan T PohligDepartment of Epidemiology, University of Delaware, Newark, Delaware, USA.
Alyssa M LanziDelaware Center for Cognitive Aging Research, University of Delaware, Newark, Delaware, USA.
Curtis L JohnsonDelaware Center for Cognitive Aging Research, University of Delaware, Newark, Delaware, USA.
Matthew L CohenDelaware Center for Cognitive Aging Research, University of Delaware, Newark, Delaware, USA.
James M EllisonDepartment of Psychiatry & Human Behavior, Thomas Jefferson University, Philadelphia, Pennsylvania, USA.

Funding

Quantifying the Influence of Pathological Hemodynamics on Cerebral Microvascular Dysfunction and Neuronal InjuryP20GM113125 · UNIVERSITY OF DELAWARE · 2025 to 2025
$2.3M
NIA NIH HHS K01 AG054731NIA NIH HHS K01AG054731NIGMS NIH HHS P20GM113125
6 · The paper itself

Abstract

introductionDeclining nicotinamide adenine dinucleotide (NAD

methodsWe conducted a 12-week double-blind, randomized, placebo-controlled pilot study to evaluate the safety, tolerability, and preliminary efficacy of the NAD

results42 participants completed the study (NR = 22, placebo = 20). Adherence was similar between groups with no serious adverse effects. Blood NAD DISCUSSION: NR effectively raises NAD

Indexed as

AmnesiaCognitive DysfunctionDietary SupplementsNiacinamideAgedAged, 80 and overBlood PressureCerebrovascular CirculationCognitive EnhancementDouble-Blind MethodFemaleHumansMaleNADNeuropsychological TestsPilot ProjectsNADNiacinamidenicotinamide-beta-ribosidePyridinium Compoundscerebral blood flowclinical trialmild cognitive impairmentNAD+nicotinamide riboside

Identifiers

PMID42478598
PMCPMC13386481

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.