ArticleBiomacromolecules2026
Design of Experiment-Assisted Development of Biodegradable Chitosan/Whey Protein Isolate Films as Advanced Pro-Regenerative Wound Dressings.
Article in Biomacromolecules, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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9 authors.
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Abstract
Chitosan (CS) and whey protein isolate (WPI) are promising biomacromolecules for wound healing; however, a rational understanding of how polymer-protein interactions influence the performance of wound dressings is still lacking. Herein, CS/WPI films were developed and optimized through a Design of Experiment (DoE) approach to investigate the influence of CS molecular weight (MW) and CS:WPI ratio on polymer-protein interactions, quantified by rheological synergism. The optimized formulation (CS:WPI 1:3 with medium-MW CS) demonstrated superior tensile strength (∼2.7 MPa), higher storage modulus (∼1 × 105 MPa in the dry state), and enhanced resistance to degradation (residual mass ∼50% after 7 days). These films showed the most pronounced antimicrobial activity against S. aureus, promoted fibroblast migration and proliferation without cytotoxic effects, and significantly enhanced wound regeneration in a murine model (5% residual wound area after 18 days). These results establish rheological synergism as an important parameter, an index of the extent of polymer-protein interactions, that are responsible of the formulation performance.
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