ArticleJournal of bioenergetics and biomembranes2026
Methotrexate potentiates oxidative stress-mediated transdifferentiation and metabolic reprogramming of neutrophils.
Article in Journal of bioenergetics and biomembranes, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Rheumatoid arthritis (RA) is associated with inflammation, oxidative stress and infiltration of immune cells (~ 90% neutrophils) into inflamed joints. Neutrophils have demonstrated the ability to transdifferentiate into 'neutrophil-dendritic cell hybrids' or N-DCs, acquire antigen presenting properties (HLA-DR/CD80/CD86) and demonstrate enhanced oxidative stress. Classical neutrophils rely mainly on glycolysis, but the bioenergetics of N-DCs remains poorly defined. Accordingly, this study aimed to assess the impact of methotrexate (MTX) on neutrophils with regard to their transdifferentiation and bioenergetics. The ex-vivo effect of MTX on neutrophils sourced from healthy controls was studied (+/- Phorbol 12-myristate 13-acetate, PMA) in terms of CD83
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