ArticleChromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology2026
Meiotic telomeres of vole B chromosomes: shelterin and associated proteins provide a link to the nuclear envelope.
Article in Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Meiotic telomeres play a critical role in chromosome dynamics, facilitating homolog pairing and synapsis through attachment to the nuclear envelope (NE). While these mechanisms are well-documented for standard A-set chromosomes, the molecular composition of supernumerary (or B) chromosome telomeres remains poorly understood. In this study, for the first time we investigated the distribution of key telomeric and NE-attachment proteins in Bs. Using immunocytochemistry and immuno-FISH on spermatocytes of the narrow-headed vole, Lasiopodomys gregalis (Rodentia, Mammalia), we identified the presence of the shelterin components RAP1, POT1 and TIN2; the LINC complex proteins SUN1 and KASH5; a major component of the nuclear lamina, Lamin B1; the regulatory kinase CDK2; and telomeric DNA specifically at the termini of meiotic supernumeraries. Our results demonstrate that despite their univalent nature and involvement in meiotic inactivation, Bs of this mammalian species possess a telomeric protein architecture that is highly similar, if even not identical, to that of A-set and sex chromosomes. These findings suggest that Bs are integrated into the meiotic machinery, utilizing standard protective and anchoring mechanisms to ensure genomic stability during prophase I.
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