Evidence map›Paper›PMID 42479366›Full record

ArticleAnnals of biomedical engineering2026

Collagen-Related Viscoelasticity as a Metric for Fracture Assessment in Cortical Bone.

Jingxiao Zhong, Jun Zhou, Chie Watanabe, Reina Tanaka, Xiaoyuan Gu, Boyang Wan, Joo-Ri Kim-Kaneyama, Yasutaka Sugamori, Junning Chen, Qing Li and 1 more

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Article in Annals of biomedical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Jingxiao ZhongSchool of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, NSW, Australia. jingxiao.zhong@mpikg.mpg.de.ORCID http://orcid.org/0000-0002-6380-0641
Jun ZhouDepartment of Biomaterials and Engineering, Showa Medical University Graduate School of Dentistry, Tokyo, Japan.
Chie WatanabeDepartment of Biomaterials and Engineering, Showa Medical University Graduate School of Dentistry, Tokyo, Japan.
Reina TanakaDepartment of Biomaterials and Engineering, Showa Medical University Graduate School of Dentistry, Tokyo, Japan.
Xiaoyuan GuDepartment of Engineering, Faculty of Environment, Science and Economy, University of Exeter, Exeter, UK.
Boyang WanSchool of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, NSW, Australia.
Joo-Ri Kim-KaneyamaInstitute for Extracellular Matrix Research, Showa Medical University, Tokyo, Japan.
Yasutaka SugamoriDepartment of Biomaterials and Engineering, Showa Medical University Graduate School of Dentistry, Tokyo, Japan.
Junning ChenSchool of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, NSW, Australia.
Qing LiSchool of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, NSW, Australia.
Yo ShibataDepartment of Biomaterials and Engineering, Showa Medical University Graduate School of Dentistry, Tokyo, Japan. yookun@dent.showa-u.ac.jp.ORCID http://orcid.org/0000-0002-1876-3298

Funding

Engineering and Physical Sciences Research Council EP/T008059/1Japan Society for the Promotion of Science 23K16036Japan Society for the Promotion of Science 25K13070
6 · The paper itself

Abstract

purposeThe mechanical competence of bone relies on both elastic stiffness and viscous damping; however, existing assessments have primarily involved stiffness quantification using bone mineral density but lack a collagen matrix-focused metric to predict fracture risk. This study introduces an experimentally anchored, time-resolved analysis framework for quantifying cortical bone matrix viscoelasticity and evaluating fracture susceptibility arising from collagen organization defects. It further proposes a collagen-related viscoelasticity metric for bone assessment.

methodsUsing murine diabetic femoral cortical bone specimens, a time-resolved viscoelastic analysis based on nanoindentation-based creep testing was performed to quantify cortical bone matrix behavior. Polarization-resolved second-harmonic generation (pSHG) microscopy was employed to characterize collagen alignment and orientation at the ultrastructural level. Finite-element simulations incorporating experimentally derived viscoelastic parameters were used to evaluate crack propagation behavior and fracture susceptibility.

resultsNanoindentation revealed a pronounced reduction in the long-term viscoelastic retardation time (

conclusionThese multimodal findings propose

Indexed as

Bone viscoelasticityCortical bone healthFracture risk assessmentMineral–collagen integrityNanoindentationPolarization-resolved second-harmonic generation microscopy

Identifiers

PMID42479366

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.