Evidence map›Paper›PMID 42479841›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

HSP90α lactylation orchestrates PGC1α and LRPGC1 nuclear translocation driving mitochondrial biogenesis.

Gang Wu, Hongmin Li, Tong He, Min Chen, Xiaoyu Jiang, Mengli Wei, Lei Zhou, Chengyu Li, Jingli Tao, Zhaojun Liu and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Gang Wu *Laboratory of Genetic Dissection and Regulation of Economically Important Traits in Animals, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.ORCID 0009-0002-5503-1384
Hongmin Li *Laboratory of Genetic Dissection and Regulation of Economically Important Traits in Animals, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Tong HeLaboratory of Genetic Dissection and Regulation of Economically Important Traits in Animals, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Min ChenLaboratory of Genetic Dissection and Regulation of Economically Important Traits in Animals, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Xiaoyu JiangLaboratory of Genetic Dissection and Regulation of Economically Important Traits in Animals, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Mengli WeiLaboratory of Genetic Dissection and Regulation of Economically Important Traits in Animals, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Lei ZhouLaboratory of Genetic Dissection and Regulation of Economically Important Traits in Animals, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Chengyu LiLaboratory of Genetic Dissection and Regulation of Economically Important Traits in Animals, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.ORCID 0000-0001-5361-4442
Jingli TaoLaboratory of Genetic Dissection and Regulation of Economically Important Traits in Animals, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.
Zhaojun LiuXinyu Agricultural Science Research Centre, Xinyu 338000, China.
Ming ShenLaboratory of Genetic Dissection and Regulation of Economically Important Traits in Animals, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.ORCID 0000-0003-1219-225X
Honglin LiuLaboratory of Genetic Dissection and Regulation of Economically Important Traits in Animals, College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, China.

Funding

the fundamental research funds for the central universities KJYQ2025002the "JBGS"project of seed industry revitalization in jiangsu province JBGS(2021)026the jiangsu agricultural science and technology innovation fund CX(20)2011the national key research and development program of China 2023YFD1300502-4the national natural science foundation of China 31972564the national natural science foundation of China 31972571the national natural science foundation of China 32472908the national natural science foundation of China 32573216the natural science foundation of jiangsu province BK20221512
6 · The paper itself

Abstract

Mitochondrial biogenesis is a fundamental process that ensures energy supply and supports steroidogenesis in ovarian cells. Lactate has recently been identified as a signaling metabolite that promotes mitochondrial biogenesis; however, the underlying regulatory mechanisms remain poorly defined. Here, we identify Heat Shock Protein 90 Alpha Family Class A Member 1 (HSP90α) lactylation as a key mediator that links glycolytic metabolism to mitochondrial function. Specifically, lactylation of HSP90α at K58 recruits ULK1, thereby enhancing phosphorylation at S39; lactylation at K616 prevents CDK5-mediated phosphorylation at S596. This dual regulation facilitates the nuclear translocation of peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC1α) and its isoform LRPGC1, which activate NRF1/2-dependent transcription of mitochondrial biogenesis genes, such as

Indexed as

HSP90 Heat-Shock ProteinsMitochondriaOrganelle BiogenesisPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaAnimalsCell NucleusEnergy MetabolismFemaleHumansMicePhosphorylationProtein TransportTranscription FactorsHSP90 Heat-Shock ProteinsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPPARGC1A protein, humanTranscription FactorsCDK5HSP90α lactylationHSP90α phosphorylationPGC1α/LRPGC1ULK1

Identifiers

PMID42479841
PMCPMC13416674

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.