Evidence map›Paper›PMID 42481649›Full record

ArticleNature immunology2026

Dysbiosis-induced expansion of AXL-positive inflammatory type 3 dendritic cells triggers preclinical autoimmunity.

Grozdan Cvijetic, Valentina Ottaviani, Isabella O Conway, Erfan Jabari, Mladen Mitrovic, Haiting Wang, Patrick Fernandes Rodrigues, Anastasia du Halgouet, Siqi Zhao, Harrison C Wang and 25 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Grozdan CvijeticImmune Regulation Unit, National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Health (NIH), Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-3263-0598
Valentina OttavianiMucosal Immunology Section, NIDCR, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0009-0006-5528-2887
Isabella O ConwayImmune Regulation Unit, National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Health (NIH), Bethesda, MD, USA.ORCID http://orcid.org/0009-0009-5987-1373
Erfan JabariImmune Regulation Unit, National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Health (NIH), Bethesda, MD, USA.
Mladen MitrovicImmune Regulation Unit, National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Health (NIH), Bethesda, MD, USA.
Haiting WangImmune Regulation Unit, National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Health (NIH), Bethesda, MD, USA.
Patrick Fernandes RodriguesDepartment of Pathology and Immunology, Washington University School of Medicine in Saint Louis, Saint Louis, MO, USA.ORCID http://orcid.org/0000-0002-0214-0627
Anastasia du HalgouetImmune Regulation Unit, National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Health (NIH), Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-8013-3716
Siqi ZhaoImmune Regulation Unit, National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Health (NIH), Bethesda, MD, USA.
Harrison C WangImmune Regulation Unit, National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Health (NIH), Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-5311-1375
Anjali P ChandrothImmune Regulation Unit, National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Health (NIH), Bethesda, MD, USA.
Robert J PalmerStructural Biochemistry Unit and Oral Immunity and Infection Section, NIDCR, NIH, Bethesda, MD, USA.
Eduard AnsaldoMetaorganism Immunity Section, Laboratory of Host Microbiome and Immunity, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-7128-3373
Andrew D DoyleNIDCR Imaging Core, NIDCR, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-0442-5415
Daniel MartinGenomics and Computational Biology Core, NIDCR, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-8880-9087
Roman SzaboImmune Regulation Unit, National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Health (NIH), Bethesda, MD, USA.
Cristina CorsinoLaboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA.
Francesca PalaLaboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA.
Miriam R FernandesLaboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute (NCI), NIH, Bethesda, MD, USA.
Nicolas BouladouxMetaorganism Immunity Section, Laboratory of Host Microbiome and Immunity, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-1593-671X
Howard A YoungCancer Innovation Laboratory, Center for Cancer Research, NCI at Frederick, Frederick, MD, USA.ORCID http://orcid.org/0000-0002-3118-5111
Yufan ZhengMolecular Mycology and Immunity Unit, Laboratory of Host Microbiome and Immunity, NIAID, NIH, Bethesda, MD, USA.
Zhaoyuan LiuShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0002-3117-0833
Florent GinhouxShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID http://orcid.org/0000-0002-2857-7755
Eric V DangMolecular Mycology and Immunity Unit, Laboratory of Host Microbiome and Immunity, NIAID, NIH, Bethesda, MD, USA.
Stephen DarnellDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
George LiechtiDepartment of Microbiology and Immunology, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-3028-8474
Michail S LionakisFungal Pathogenesis Section, Laboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-4994-9500
Robert IvanekDepartment of Biomedicine, University of Basel, Basel, Switzerland.ORCID http://orcid.org/0000-0002-8403-056X
Luigi D NotarangeloLaboratory of Clinical Immunology and Microbiology, NIAID, NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0002-8335-0262
Yasmine BelkaidMetaorganism Immunity Section, Laboratory of Host Microbiome and Immunity, National Institute of Allergy and Infectious Diseases (NIAID), NIH, Bethesda, MD, USA.
WanJun ChenMucosal Immunology Section, NIDCR, NIH, Bethesda, MD, USA.
Amiran DzutsevLaboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute (NCI), NIH, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-0749-4149
Giorgio TrinchieriLaboratory of Integrative Cancer Immunology, Center for Cancer Research, National Cancer Institute (NCI), NIH, Bethesda, MD, USA.
Roxane TussiwandImmune Regulation Unit, National Institute of Dental and Craniofacial Research (NIDCR), National Institute of Health (NIH), Bethesda, MD, USA. roxane.tussiwand@uni-bonn.de.ORCID http://orcid.org/0000-0002-1712-868X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Conventional dendritic cells (cDCs) are key sentinels at epithelial barriers, regulating immunity to microbial pathogens and commensals while preserving tissue integrity. NOTCH2 deficiency in CD11c-expressing cells (Notch2

Identifiers

PMID42481649

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.