Evidence map›Paper›PMID 42482242›Full record

ArticleJournal of nanobiotechnology2026

Virosome-masked ratiometric nanoprobes for in vivo dynamic imaging of influenza a virus infection.

Ruiqi Ming, Yue Wang, Zewei Yan, Shujun Liu, Zhongjie Wang, Hanlin Chen, Yingjie Shi, Yuantian Jing, Rui Zhang, Shasha Peng and 5 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Ruiqi MingSchool of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China.
Yue WangDepartment of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application, Chinese Academy of Medical Sciences, Beijing, 100730, P. R. China.
Zewei YanSchool of Life Sciences, Inner Mongolia Normal University, Hohhot, 010022, P. R. China.
Shujun LiuSchool of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China.
Zhongjie WangSchool of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China.
Hanlin ChenSchool of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China.
Yingjie ShiDepartment of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application, Chinese Academy of Medical Sciences, Beijing, 100730, P. R. China.
Yuantian JingSchool of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China.
Rui ZhangSchool of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China.
Shasha PengSchool of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China.
Jiajie TianSchool of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China.
Yimei PanSchool of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China.
Wenfeng XuDepartment of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application, Chinese Academy of Medical Sciences, Beijing, 100730, P. R. China.
Pengfei JinDepartment of Pharmacy, Beijing Hospital, National Center of Gerontology, Institute of Geriatric Medicine, Beijing Key Laboratory of Assessment of Clinical Drugs Risk and Individual Application, Chinese Academy of Medical Sciences, Beijing, 100730, P. R. China. j790101@163.com.
Li-Li HuangSchool of Medical Science and Engineering, Beijing Institute of Technology, Beijing, 100081, P. R. China. llhuang@bit.edu.cn.

Funding

Beijing Chen Jumei Public Welfare Foundation 202524141003ABeijing Natural Science Foundation-Haidian Original Innovation Joint Program L242138Hebei Natural Science Foundation B2024105013Henan Province Science and Technology Research Project 252102310424National Natural Science Foundation of China 22274011
6 · The paper itself

Abstract

In vivo fluorescent in situ visualization of viral infection dynamics is crucial for elucidating the mechanisms of viral pathogenesis. However, current approaches lack sufficient specificity and sensitivity for spatiotemporal monitoring of viral infection in vivo. Here, we proposed virosome-masked ratiometric nanoprobes (VMR-NPs) integrated with dual-stimuli-responsive near-infrared (NIR) Förster resonance energy transfer (FRET) reporters that specifically recognize influenza A virus (IAV) viral RNA (vRNA) and apurinic/apyrimidinic endonuclease 1 (APE1). Surface hemagglutinin (HA) envelope protein of IAV virosome endows VMR-NPs with enhanced host-cell association and IAV-like intracellular trafficking behavior. Following internalization, vRNA recognition together with APE1-assisted signal amplification modulates the ratiometric fluorescence output of VMR-NPs, enabling sensitive detection of infection-associated signal changes in vitro and in vivo. This study establishes an IAV virosome-masked sensing platform for imaging infection-associated IAV burden and provides a useful tool for studying virus-related biological processes.

Indexed as

Influenza A virusNanoparticlesOrthomyxoviridae InfectionsAnimalsDogsFluorescence Resonance Energy TransferFluorescent DyesHumansMadin Darby Canine Kidney CellsMiceRNA, ViralFluorescent DyesRNA, ViralIn situ monitoringRatiometric nanoprobeSignal amplificationSpatiotemporal trackingVirosome

Identifiers

PMID42482242

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.