ReviewPediatrics international : official journal of the Japan Pediatric Society
ACE2/Angiotensin 1-7/Mas Receptor Axis in Thermogenic Adipose Tissue: Age-Related Implications for Pediatric Obesity.
Review in Pediatrics international : official journal of the Japan Pediatric Society. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Pediatric obesity is a growing global health challenge, and effective and sustainable therapeutic options remain limited. Although lifestyle modifications remain the cornerstone of treatment, pharmacological and surgical interventions are restricted among pediatric populations, highlighting the need for novel pathophysiology-based strategies. Increasing evidence indicates that the renin-angiotensin system, particularly the nonclassical angiotensin-converting enzyme 2 (ACE2)/angiotensin 1-7 (Ang1-7)/Mas receptor (MasR) axis, plays an important role in metabolic regulation beyond classical cardiovascular functions. The ACE2/Ang1-7/MasR axis exerts pleiotropic metabolic effects, including anti-inflammatory and insulin-sensitizing actions, and has emerged as a key regulator of adipose tissue biology. Experimental studies have demonstrated that activation of this pathway stimulates brown adipose tissue (BAT), induces browning of white adipose tissue (WAT), and increases energy expenditure, thereby attenuating diet-induced obesity and attracting considerable attention as potential therapeutic targets. However, accumulating evidence from human imaging studies and experimental models suggests that BAT activity and thermogenic plasticity decline with age, which may affect the metabolic efficacy of interventions targeting thermogenic adipose tissue. Age-related differences in adipose tissue responsiveness may therefore contribute to discrepancies among previous studies examining Ang1-7-mediated thermogenic effects. This review summarized the current evidence regarding the role of the ACE2/Ang1-7/MasR axis in regulating thermogenic adipose tissue, with a focus on BAT activation and WAT browning in obesity. We further discuss age-related considerations that may modulate responsiveness to this pathway. Given that BAT activity is intrinsically high during childhood and adolescence, ACE2/Ang1-7 axis modulation may represent a promising therapeutic strategy for pediatric obesity.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.