ArticleFrontiers in microbiology2026
Modulation of gut microbiota and intestinal barrier by lotus seed, jujube, and longan aril in senna leaf-induced diarrhea in mice.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: This study aimed to investigate the regulatory effects of lotus seed, jujube, and longan aril on the gut microbiota structure and barrier function in a senna leaf-induced diarrhea mouse model. Methods: Diarrhea was induced in ICR mice using senna leaf extract. Mice received aqueous extracts of lotus seed, jujube, or longan aril for treatment. Intestinal motility was assessed through fecal consistency scoring and the charcoal propulsion test. Colon tissues were collected for histopathological examination using H&E staining, as well as immunohistochemical and Western blot analyses of aquaporin 3 (AQP3) and sodium-hydrogen exchanger 8 (NHE8). Gut microbiota composition was analyzed via 16S rRNA sequencing. Results: All three herbal interventions significantly reduced the loose stool rate and diarrhea index ( Conclusion: Lotus seed, jujube, and longan aril synergistically alleviated diarrhea via multiple pathways, including modulation of gut microbiota structure, repair of barrier function, balance of water-electrolyte metabolism, and inhibition of intestinal hypermotility. This study provides a scientific foundation for the clinical application of medicinal and edible homology substances, as well as the development of microecological agents.
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