ArticleFrontiers in neurology2025
A prediction for sepsis in adult patients with severe cerebrovascular disease from neurological intensive care unit.
Article in Frontiers in neurology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Flunarizine and cinnarizine in the prophylaxis of vestibular migraine and migraine-associated menière's disease: An 8-month retrospective study.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026Article
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7 authors.
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Abstract
Background: Sepsis is one of the common causes of death in the neurological intensive care unit (NICU) stroke patients, the aim of this study was to evaluate the diagnostic performance of blood biomarkers studied for the early diagnosis of sepsis in ICU hospitalized patients with acute moderate to severe stroke, and to establish a that is specifically used to predict the occurrence of sepsis or not after stroke. Methods: A prediction model was built including 157 patients with severe cerebrovascular disease [including acute ischemic stroke (AIS) or cerebral hemorrhage (ICH)] who had National Institute of Health stroke scale (NIHSS) >14 or Glasgow coma scale (GCS) <8 from January 2020 to November 2022 in NICU. Laboratory parameters and clinical characteristics of the patients were collected as well as Enzyme-Linked Immunosorbent Assay (ELISA) to detect blood biomarkers IL-10, MIP-1β, TNF-α, nNOS, iNOS, MMP-9, S-100β, and ET-1 within 48 h after symptom onset. Multi-factorial logistic regression was used to construct for predicting sepsis in patients with acute moderate-to-severe stroke, and internal validation was evaluated using bootstrap validation. The performance of the graph was assessed based on its calibration, discrimination, and clinical utility. Results: The prevalence of sepsis in acute moderate-to-severe stroke patients was 12.1%. The GCS scores of patients with comorbidity sepsis were all lower than those of patients without sepsis, and the NIHSS scores were higher than those of patients without sepsis. Logistic stepwise regression was performed to identify 4 variables Hyperlipidaemia (
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