ArticleFrontiers in cellular and infection microbiology2026
Persistent pancreatic enzyme elevation is correlated with superinfection in acute pancreatitis with fluid collections: a prospective, multicentre cohort analysis.
Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Superinfection of pancreatic fluid collections (PFCs) is a major determinant of late morbidity and mortality in acute pancreatitis (AP). Persistent Pancreatic Enzyme Elevation (PPEE), may contribute to fluid stasis and infection; however, its clinical impact remains incompletely defined. Methods: From 3,694 patients with AP enrolled in the Acute Pancreatitis Registry (2012-2023, 22 centres), 912 patients with PFCs were analysed. Based on pancreatic enzyme dynamics, patients were classified as having PPEE (n=276; amylase or lipase level ≥300U/l for at least one day, or mean amylase or lipase level ≥150U/l on or after day 5 of admission) or normal enzyme kinetics (NEK) (n=503). The primary outcome was PFC infection rate; secondary outcomes included mortality, organ failure, Intensive Care Unit (ICU) requirement, need for intervention, and length of hospitalisation (LOH). Results: Patients with PPEE were younger (mean age: 56.9 Conclusion: PPEE are associated with an increased risk of superinfection and the need for intervention in PFCs, without affecting disease severity or mortality in AP. Regular enzyme monitoring and early ductal assessment may enhance patient management.
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