ArticleCureus2026
Autoimmune/Inflammatory Syndrome Induced by Hyaluronic Acid and Hyaluronidase.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skin aging is a biological and chronological process characterized by progressive alterations in the extracellular matrix, including reduced hyaluronic acid (HA) content. HA dermal fillers are widely used for cosmetic purposes and are generally considered safe; however, immune-mediated complications, including autoimmune/inflammatory syndrome induced by adjuvants (ASIA), have been increasingly reported. We report the case of a 35-year-old White woman who underwent cosmetic lip augmentation with HA and subsequently developed multisystem manifestations consistent with ASIA. Due to persistent local and systemic symptoms, hyaluronidase was administered; however, her condition deteriorated, with progression to systemic involvement. Clinical features included sicca symptoms, Raynaud's phenomenon, and cognitive impairment with reduced concentration and memory, severe fatigue, and progressive cutaneous changes characterized by skin laxity and hyperextensibility, compatible with acquired cutis laxa. Despite treatment with high-dose corticosteroids, methotrexate, analgesics, and antidepressants, no significant clinical improvement was observed. This case highlights the potential for severe immune-mediated and connective tissue complications following exposure to HA and hyaluronidase. Awareness of ASIA and its atypical manifestations, including acquired cutis laxa, is essential for early recognition and appropriate management of patients undergoing cosmetic procedures.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.