Evidence map›Paper›PMID 42483274›Full record

ArticleCell press blue2026

NodoMap: A single-cell and spatial transcriptomic atlas of the mouse nodose ganglion.

Sijing Cheng, Georgina K C Dowsett, Kara Rainbow, Mariana Norton, Anna G Roberts, Phyllis Phuah, Gavin A Bewick, Brian Y H Lam, Giles S H Yeo, Kevin G Murphy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell press blue, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Sijing ChengDivision of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Hammersmith Hospital, 6th Floor Commonwealth Building, London W12 0NN, UK.
Georgina K C DowsettMRC Metabolic Diseases Unit, Institute of Metabolic Science Metabolic Research Laboratories, University of Cambridge, Cambridge CB2 0QQ, UK.
Kara RainbowMRC Metabolic Diseases Unit, Institute of Metabolic Science Metabolic Research Laboratories, University of Cambridge, Cambridge CB2 0QQ, UK.
Mariana NortonDivision of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Hammersmith Hospital, 6th Floor Commonwealth Building, London W12 0NN, UK.
Anna G RobertsDivision of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Hammersmith Hospital, 6th Floor Commonwealth Building, London W12 0NN, UK.
Phyllis PhuahDivision of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Hammersmith Hospital, 6th Floor Commonwealth Building, London W12 0NN, UK.
Gavin A BewickDiabetes and Obesity Theme, School of Cardiovascular and Metabolic Medicine and Sciences, Faculty of Life Sciences and Medicine, King's College London, London SE1 1UL, UK.
Brian Y H LamMRC Metabolic Diseases Unit, Institute of Metabolic Science Metabolic Research Laboratories, University of Cambridge, Cambridge CB2 0QQ, UK.
Giles S H YeoMRC Metabolic Diseases Unit, Institute of Metabolic Science Metabolic Research Laboratories, University of Cambridge, Cambridge CB2 0QQ, UK.
Kevin G MurphyDivision of Diabetes, Endocrinology and Metabolism, Department of Metabolism, Digestion, and Reproduction, Faculty of Medicine, Hammersmith Hospital, 6th Floor Commonwealth Building, London W12 0NN, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The vagus nerve is a central component of the parasympathetic nervous system, innervating multiple abdominal organs to monitor and regulate their function. Vagal sensory neuron cell bodies reside in the nodose ganglia, but their molecular diversity and spatial organization remain incompletely defined. Here, we generated and integrated single-nucleus RNA sequencing (snRNA-seq) data with multiple published datasets to construct a unified atlas of 106,436 cells and combined this with spatial transcriptomics to create a single-cell and spatial map of the mouse nodose ganglion (NodoMap). We identify 21 neuronal subtypes and multiple non-neuronal populations, revealing subtype-specific gene expression differences between left and right ganglia and transcriptional responses to fasting. Spatial analysis shows intermingled neuronal populations with distinct cellular neighborhoods. Together, NodoMap provides a high-resolution resource for dissecting vagal sensory circuits and identifying molecular targets involved in energy homeostasis and metabolic disease.

Indexed as

dorsal-vagal complexgut-brain axisnodose gangliavagus

Identifiers

PMID42483274
PMCPMC13385471

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.