ArticleFrontiers in pediatrics2026
Effects of TNF-α, IL-1β and IL-2 on regulatory T cells in children with idiopathic nephrotic syndrome.
Article in Frontiers in pediatrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Purpose: The pathogenesis of idiopathic nephrotic syndrome (INS) is unknown, but previous studies suggested that alterations of immune cells and cytokines have a role. We investigated the effects of multiple cytokines on the level of regulatory T cells (Tregs) in children with INS. Methods: Blood samples were collected from children with INS before and after glucocorticoid therapy and from age-matched healthy controls. The proportions of CD4 Results: Compared with controls, children with active INS showed significantly decreased proportions of Tregs and reduced expression of Conclusion: Patients with active INS have an increased level of TNF-α, which downregulated
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