Evidence map›Paper›PMID 42483595›Full record

ReviewEnvironment & health (Washington, D.C.)2026

Insights into the Neurotoxicology of Traditional and Emerging Per- and Polyfluoroalkyl Substances: Mechanisms and Research Frontiers.

Zhihua Ren, Xiao Wang, Lingyi Meng, Danqin Ren, Jiafei Sun, Yixue Cai, Yonghui Duan, Xia Ning, Tingting Ku, Nan Sang

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Environment & health (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. AEnvironment & health (Washington, D.C.) · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zhihua RenShanxi Key Laboratory of Coal-Based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan 030006, China.
Xiao WangShanxi Key Laboratory of Coal-Based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan 030006, China.
Lingyi MengState Key Laboratory of Environmental Criteria and Risk Assessment, National Joint Research Center for Ecological Conservation and High Quality Development of the Yellow River Basin, Chinese Research Academy of Environmental Sciences, Beijing 100012, China.ORCID https://orcid.org/0009-0006-5164-6815
Danqin RenShanxi Key Laboratory of Coal-Based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan 030006, China.
Jiafei SunShanxi Key Laboratory of Coal-Based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan 030006, China.
Yixue CaiShanxi Key Laboratory of Coal-Based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan 030006, China.
Yonghui DuanShanxi Key Laboratory of Coal-Based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan 030006, China.
Xia NingShanxi Key Laboratory of Coal-Based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan 030006, China.
Tingting KuShanxi Key Laboratory of Coal-Based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan 030006, China.ORCID https://orcid.org/0000-0001-9478-0201
Nan SangShanxi Key Laboratory of Coal-Based Emerging Pollutant Identification and Risk Control, Research Center of Environment and Health, College of Environment and Resource, Shanxi University, Taiyuan 030006, China.ORCID https://orcid.org/0000-0002-2433-3200

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Per- and polyfluoroalkyl substances (PFASs), colloquially termed "forever chemicals" due to their environmental persistence, are characterized by the inherent chemical stability that facilitates global dissemination and bioaccumulation, leading to their ubiquitous detection in environmental and biological matrices. Substantial concerns regarding the adverse health implications of traditional PFASs, notably perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA), which encompass multiple biological negative effects, have precipitated regulatory restrictions and phase-out. This regulatory shift has spurred the introduction of substitutes, yet emerging evidence indicates that these replacements have themselves become pervasive contaminants, such as chlorinated polyfluoroalkyl ether sulfonate (Cl-PFAES, F-53B) and hexafluoropropylene oxide dimer acid (HFPO-DA, Genx), which have been shown to possess toxicological profiles comparable to or exceeding those of their predecessors. The present review aims to comprehensively synthesize the current state of knowledge concerning the neurotoxicity of traditional and emerging PFASs, integrating insights from epidemiological studies, elucidation of central nervous system (CNS) penetration mechanisms,

Indexed as

molecular mechanismneurodevelopmental toxicityneurotoxicityper- and polyfluoroalkyl substances (PFASs)traditional and emerging PFASs

Identifiers

PMID42483595
PMCPMC13386386

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.