ArticleSmall science2026
Intrinsically Disordered Polypeptides-Based Stealth Materials Enable Enhanced Photothermal Cancer Therapy Using an In Situ Fiber-Based Penetrating Laser System.
Article in Small science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Photothermal therapy has emerged as a minimally invasive cancer treatment strategy, yet poor nanoparticle (NP) stability, nonspecific accumulation, and inefficient laser delivery to deep tumor tissues markedly limit conventional approaches. Here, we report the rational design of intrinsically disordered polypeptides (IDPs) as next-generation stealth materials for photothermal cancer therapy applications using a novel contact-mode laser irradiation system. IDP1 was computationally designed as a hydrophilic IDP inspired by albumin's primary sequence. IDP1 exhibited an exceptional fourfold prolonged blood circulation half-life (
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