ArticleRevista da Associacao Medica Brasileira (1992)2026
Do serum homocysteine levels affect female sexual function in reproductive-age women: a cross-sectional study.
Article in Revista da Associacao Medica Brasileira (1992), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to investigate the association between serum homocysteine levels and female sexual function in reproductive-age women presenting with sexual dysfunction complaints and to evaluate relationships with vitamin B12 and folic acid levels.
methodsThis cross-sectional study included 114 sexually active women aged 18-45 years presenting with sexual dysfunction complaints. Female sexual function was assessed using the Female Sexual Function Index. Fasting serum homocysteine, vitamin B12, and folic acid levels were measured. Correlation analyses, group comparisons, and multivariable linear regression were performed. A priori sample size calculation indicated that at least 84 participants were required to detect a moderate correlation (ρ=0.30) with 80% power.
resultsFemale Sexual Function Index scores were available for 111 participants and homocysteine levels for 99 participants. The mean Female Sexual Function Index total score was 24.69±4.34, below the established cut-off for sexual dysfunction. Serum homocysteine levels were not associated with Female Sexual Function Index total or domain scores (ρ=-0.035, p=0.726). No significant differences were observed between homocysteine groups defined by ≤10 and >10 μmol/L or ≤15 and >15 μmol/L. Age showed a moderate negative correlation with the desire domain (ρ=-0.362, p<0.001). In multivariable regression, homocysteine, vitamin B12, and folic acid were not independent predictors of Female Sexual Function Index total score.
conclusionIn this symptomatic population, homocysteine levels were not associated with female sexual function. These findings should be interpreted cautiously due to the lack of a control group. Further large-scale, population-based studies are needed.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.