Evidence map›Paper›PMID 42484704›Full record

ArticleMolecular biology reports2026

SLCO1B1 and MTRR gene variants in pediatric acute lymphoblastic leukemia: a study on Egyptian children.

Ali Nabeel Mahdi, Afaf M Elsaid, Maha Abdelmoneim Mohammed, Mai M Madkour, A F Abdel-Aziz

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Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Ali Nabeel MahdiBiochemistry Division, Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt.
Afaf M ElsaidMansoura Children Hospital, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.
Maha Abdelmoneim MohammedHematology and Oncology unit, Faculty of Medicine, Mansoura University, Mansoura, 35516, Egypt.
Mai M MadkourBiochemistry Division, Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt. maimadkour211@mans.edu.eg.
A F Abdel-AzizBiochemistry Division, Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, 35516, Egypt. afaziz2012@hotmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAcute lymphoblastic leukemia (ALL) is the most common malignancy in pediatric populations and affects white blood cells. The solute carrier organic anion transporter family member 1B1 (SLCO1B1) gene encodes the organic anion transporting polypeptide 1B1 (OATP1B1), a transporter involved in drug metabolism, whereas methionine synthase reductase (MTRR) plays an essential role in DNA synthesis and methylation. This study investigated the association between pediatric ALL and genetic polymorphisms in the SLCO1B1 and MTRR genes in an Egyptian population.

methodsTetra-primer amplification refractory mutation polymerase chain reaction (T-ARMS-PCR) was used to genotype the SLCO1B1 (521T > C, rs4149056) and MTRR (1049 A > G, rs162036) variants in 100 pediatric ALL patients and 100 healthy controls.

resultsSignificant differences in genotype and allele frequencies were observed between cases and controls for both variants (SLCO1B1: p = 0.001; MTRR: p = 0.001 and p = 0.04, respectively).

conclusionsThese findings suggest a possible association between SLCO1B1 and MTRR polymorphisms and susceptibility to pediatric ALL in the studied Egyptian population.

Indexed as

Ferredoxin-NADP ReductaseLiver-Specific Organic Anion Transporter 1Precursor Cell Lymphoblastic Leukemia-LymphomaAdolescentCase-Control StudiesChildChild, PreschoolEgyptFemaleGene FrequencyGenetic Predisposition to DiseaseGenotypeHumansInfantMalePolymorphism, Single NucleotideFerredoxin-NADP ReductaseLiver-Specific Organic Anion Transporter 1methionine synthase reductaseSLCO1B1 protein, humanAcute lymphoblastic leukemiaMethionine synthase reductase genePolymorphismSolute carrier organic anion transporter 1B1

Identifiers

PMID42484704

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.