ReviewTechnology in cancer research & treatment
Caught in the NET: A Review on the Emerging Role of Neutrophil Extracellular Traps in PDAC Development.
Review in Technology in cancer research & treatment. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
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Authors and funding
3 authors.
Funding
Abstract
Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, characterized by poor treatment response. A part of this dismal prognosis can be attributed to the immunosuppressive tumor microenvironment (TME) that renders tumors anti-immunogenic and resistant to immunotherapies. Neutrophil extracellular traps (NETs) are a frontline defense in pathogen clearance. However, NETs also play a destructive role in many chronic conditions, such as autoimmune disease and cancer. Recent evidence corroborates the impact of NETs on PDACs pathogenesis by promoting tumor progression and enhancing the immunosuppressive TME. As such, NETs have become an attractive therapeutic target to improve patient outcomes. This review addresses the current research findings on the association of NETs and PDAC progression and future research opportunities in targeted NET therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.