ArticleSTAR protocols2026
A 3D RNA-protein proximity ligation protocol detecting the heterogeneity of LISRR-RPL26 interactions in patient-derived melanoma tumor explants.
Article in STAR protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Investigating lncRNA-protein interactors is crucial for understanding their contribution to tumor formation and progression. Here, we present a protocol to explore the heterogeneity of RNA-protein interactions between the lncRNA LISRR and RPL26 ex vivo in 3D clinically relevant patient-derived melanoma models. We describe steps for sample preparation, RNA probe hybridization, and a proximity ligation assay. We then detail procedures for detection and analysis. This protocol bypasses tissue embedding and sectioning, significantly accelerating data acquisition.
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