Evidence map›Paper›PMID 42485432›Full record

ArticleScience translational medicine2026

Live attenuated vaccines alone or in combination with an adenovirus-based vaccine protect mice lacking IFN-γ against pneumonic plague.

Emily K Hendrix, Jian Sha, Paul B Kilgore, Blake H Neil, Atul K Verma, Heidi Spratt, Ashok K Chopra

Abstract read
In one paragraph

Article in Science translational medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Emily K HendrixDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-0374-3841
Jian ShaDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0009-0003-7638-9067
Paul B KilgoreDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0003-2474-8120
Blake H NeilDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0009-0002-8091-0604
Atul K VermaDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0001-8173-330X
Heidi SprattSchool of Public and Population Health, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-9420-5028
Ashok K ChopraDepartment of Microbiology & Immunology, University of Texas Medical Branch, Galveston, TX 77555, USA.ORCID 0000-0002-5223-3012

Funding

Immunological characterization of rationally-designed vaccines against plague in mice and non-human primate modelsR01AI153524 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CHOPRA, ASHOK K · 2021 to 2025
$3.1M
Biodefense Training ProgramT32AI060549 · NIAID · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI ASHOK K CHOPRA, Janice J Endsley · 2004 to 2026
$3.0M
Evaluation and Production of a Multivalent Adenoviral Plague VaccineR44AI071634 · NIAID · NORWELL, INC. · PI CHOPRA, ASHOK K, ROTHE, ERIC · 2012 to 2014
$2.9M
Development, Production and Evaluation of a Multivalent Adenoviral Plague VaccineR43AI071634 · NIAID · NORWELL, INC. · PI LENTZ, CHRIS · 2008 to 2009
$532k
Immunological characterization of rationally-designed vaccines against plague in mice and non-human primate modelsR56AI153524 · NIAID · UNIVERSITY OF TEXAS MED BR GALVESTON · PI CHOPRA, ASHOK K · 2020 to 2020
$225k
NIAID NIH HHS R01 AI153524NIAID NIH HHS R43 AI071634NIAID NIH HHS R44 AI071634NIAID NIH HHS R56 AI153524NIAID NIH HHS T32 AI060549
6 · The paper itself

Abstract

Two live-attenuated vaccines, LMA and LMP, were evaluated alone or in combination with a trivalent adenoviral vector-based vaccine (Ad5-YFV) for their protective efficacy against pneumonic plague in wild-type (WT) and interferon-γ (IFN-γ) knockout (KO) mice. LMA and LMP comprise triple deletion mutants of

Indexed as

AdenoviridaeInterferon-gammaPlaguePlague VaccineVaccines, AttenuatedAnimalsFemaleLungMiceMice, Inbred C57BLMice, KnockoutT-LymphocytesYersinia pestisInterferon-gammaPlague VaccineVaccines, Attenuated

Identifiers

PMID42485432
PMCPMC13592400

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.