ArticleArchives of endocrinology and metabolism2026
Association between triglyceride to high-density lipoprotein cholesterol ratio and new-onset diabetes mellitus.
Article in Archives of endocrinology and metabolism, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveTo examine the association between triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio and the onset of diabetes mellitus (DM) within an ongoing prospective cohort in China. SUBJECTS AND
methodsParticipants were categorized into four groups according to their TG/HDL-C ratio quartiles. Kaplan-Meier estimator determined the cumulative incidence during follow-up and generated time-to-event curves. Additionally, a Cox proportional hazards regression analysis assessed the hazard ratios (HRs) and their corresponding 95% confidence intervals (CIs) for new-onset DM. A sensitivity analysis was also performed to mitigate the possible effects of reverse causation.
resultsDuring a median follow-up duration of 13.67 years, 38,210 individuals developed DM. Kaplan-Meier curves revealed that the cumulative DM incidence across quartiles 1 to 4 was 40.95%, 42.04%, 41.42%, and 44.38%, respectively. The risk of developing DM increased over time according to the baseline TG/HDL-C ratio quartiles. After adjusting for potential confounding variables, the HRs reached 1.045 (95% CI, 1.015-1.076), 1.026 (95% CI, 0.996-1.058), and 1.095 (95% CI, 1.058-1.133) for quartiles 2, 3, and 4, respectively (P for trend < 0.001). These findings were consistent in sensitivity analyses, with HRs of 1.045 (95% CI, 1.016-1.075), 1.026 (95% CI, 0.996-1.058), and 1.095 (95% CI, 1.058-1.133) for quartiles 2, 3, and 4, respectively (P for trend < 0.0001).
conclusionTG/HDL-C ratio is significantly and positively associated with new-onset DM.
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