ArticleACS nano2026
Hybrid Nonviral Nanocarriers Enable Functional Neural Modulation.
Eunji Hong, Xinxin Xu, Sizhe Huang, Geunho Jang, Zuer Wu, Qianbin Wang, Siyuan Rao
Abstract read
In one paragraphArticle in ACS nano, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
7 authors.
Eunji HongDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York13902, United States.ORCID 0000-0003-3294-1780 Xinxin XuDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York13902, United States.
Sizhe HuangDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York13902, United States.
Geunho JangDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York13902, United States.
Zuer WuDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York13902, United States.
Qianbin WangDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York13902, United States.ORCID 0000-0002-9840-6732 Siyuan RaoDepartment of Biomedical Engineering, Binghamton University, State University of New York, Binghamton, New York13902, United States.ORCID 0000-0002-1555-487X Funding
Magnetic Modulation on Targeted Neural Circuits in AutismR00MH120279 · NIMH · UNIVERSITY OF MASSACHUSETTS AMHERST · PI RAO, SIYUAN · 2021 to 2023
$747kIdentifying Cellular Intraspinal Electrophysiological Features of "Spinal Shock"R21NS144777 · NINDS · STATE UNIVERSITY OF NY,BINGHAMTON · PI HE, ZHIGANG, RAO, SIYUAN · 2025 to 2025
$470kAir Force Office of Scientific Research Young Investigator Program, FA9550-23-1-0339Binghamton University Faculty Startup FundsBinghamton University S3IP Small Grant Awards, ADLG 267Binghamton University S3IP Small Grant Awards, ADLG 274Binghamton University S3IP Small Grant Awards, ADLG 324Binghamton University Transdisciplinary Areas of Excellence (TAE) prograBinghamton University Watson College of Engineering and Applied ScienceBrain and Behavior Research Foundation Young Investigator Grant, 29878Craig H. Neilsen Foundation SCIRTS Pilot Research Grant, 1348565National Institutes of Health (NIH) R00MH120279National Institutes of Health (NIH) R21NS144777National Science Foundation (NSF) Faculty Early Career Development Program, 2414753National Science Foundation (NSF) Faculty Early Career Development Program, 2442112NIMH NIH HHS R00 MH120279NINDS NIH HHS R21 NS144777S.H. Ho Foundation Research Grants Health Sciences and Technology
6 · The paper itselfAbstract
Extracellular vesicles released from the neuronal cells mediate the transfer of proteins, nucleic acids, and neurotransmitter-related cargoes, shaping gene expression and intercellular communication across neural circuits. Leveraging this endogenous pathway, we fused astrocyte-derived exosomes with RNA-loaded synthetic liposomes to create sub-100 nm hybrid nanoparticles for central nervous system delivery. This design addresses key limitations of existing systems: conventional liposomes lack cell-type specificity and can be toxic, whereas native vesicles are difficult to load efficiently. By tuning a mildly cationic surface, the hybrids support efficient gene transfer to neurons without disrupting membrane integrity or inducing measurable cytotoxicity. We validated this platform in vivo by delivering Cre recombinase mRNA in transgenic mice and inducing channel rhodopsin-2 expression in the motor cortex and ventral tegmental area, yielding behavioral changes during optogenetic stimulation.
Indexed as
Gene Transfer TechniquesNanoparticlesNeuronsAnimalsAstrocytesExosomesIntegrasesLiposomesMiceMice, TransgenicOptogeneticsRNA, MessengerCre recombinaseIntegrasesLiposomesRNA, Messengerexosomesgene deliveryliposomesneural modulationnonviral nanocarriersoptogenetics
Identifiers
PMID42485583
PMCPMC13450448
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